Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients

Rashid Ramazanzadeh, Parissa Farnia, Nour Amirmozafari, Farideh Ghazi, Zeinab Ghadertotonchi, Jaber Kamran, Frouzan Mohammadi, Mehdi Mirsaedi, Mohammadreza Masjedi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90%) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4% of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalChemotherapy
Volume52
Issue number6
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Drugs
  • Resistance
  • Spoligotyping
  • Tuberculosis

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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