Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients

Rashid Ramazanzadeh, Parissa Farnia, Nour Amirmozafari, Farideh Ghazi, Zeinab Ghadertotonchi, Jaber Kamran, Frouzan Mohammadi, Mehdi Mirsaeidi, Mohammadreza Masjedi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90%) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4% of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalChemotherapy
Volume52
Issue number6
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Molecular Epidemiology
Mycobacterium tuberculosis
Drug Resistance
Multiple Drug Resistance
Multidrug-Resistant Tuberculosis
Iran
Tuberculosis
Bacteria
Pharmaceutical Preparations
Beijing

Keywords

  • Drugs
  • Resistance
  • Spoligotyping
  • Tuberculosis

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients. / Ramazanzadeh, Rashid; Farnia, Parissa; Amirmozafari, Nour; Ghazi, Farideh; Ghadertotonchi, Zeinab; Kamran, Jaber; Mohammadi, Frouzan; Mirsaeidi, Mehdi; Masjedi, Mohammadreza.

In: Chemotherapy, Vol. 52, No. 6, 10.2006, p. 316-320.

Research output: Contribution to journalArticle

Ramazanzadeh, R, Farnia, P, Amirmozafari, N, Ghazi, F, Ghadertotonchi, Z, Kamran, J, Mohammadi, F, Mirsaeidi, M & Masjedi, M 2006, 'Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients', Chemotherapy, vol. 52, no. 6, pp. 316-320. https://doi.org/10.1159/000095971
Ramazanzadeh, Rashid ; Farnia, Parissa ; Amirmozafari, Nour ; Ghazi, Farideh ; Ghadertotonchi, Zeinab ; Kamran, Jaber ; Mohammadi, Frouzan ; Mirsaeidi, Mehdi ; Masjedi, Mohammadreza. / Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients. In: Chemotherapy. 2006 ; Vol. 52, No. 6. pp. 316-320.
@article{ed6131cf68974f04aaa72ccc0d1bd1c4,
title = "Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients",
abstract = "The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90{\%}) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4{\%} of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.",
keywords = "Drugs, Resistance, Spoligotyping, Tuberculosis",
author = "Rashid Ramazanzadeh and Parissa Farnia and Nour Amirmozafari and Farideh Ghazi and Zeinab Ghadertotonchi and Jaber Kamran and Frouzan Mohammadi and Mehdi Mirsaeidi and Mohammadreza Masjedi",
year = "2006",
month = "10",
doi = "10.1159/000095971",
language = "English (US)",
volume = "52",
pages = "316--320",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients

AU - Ramazanzadeh, Rashid

AU - Farnia, Parissa

AU - Amirmozafari, Nour

AU - Ghazi, Farideh

AU - Ghadertotonchi, Zeinab

AU - Kamran, Jaber

AU - Mohammadi, Frouzan

AU - Mirsaeidi, Mehdi

AU - Masjedi, Mohammadreza

PY - 2006/10

Y1 - 2006/10

N2 - The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90%) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4% of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.

AB - The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90%) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4% of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.

KW - Drugs

KW - Resistance

KW - Spoligotyping

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=33750268806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750268806&partnerID=8YFLogxK

U2 - 10.1159/000095971

DO - 10.1159/000095971

M3 - Article

C2 - 17008783

AN - SCOPUS:33750268806

VL - 52

SP - 316

EP - 320

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 6

ER -