Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease

Jordi A. Matias-Guiu, María Nieves Cabrera-Martín, Rosie Curiel Cid, María Valles-Salgado, Teresa Rognoni, Teresa Moreno-Ramos, José Luis Carreras, David Loewenstein, Jorge Matías-Guiu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. Objective: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference. Methods: Fifty patients consulting for subjective memory complaints without functional impairment and at risk for AD were enrolled and evaluated using FCSRT, LASSI-L, and FDG-PET. Participants were evaluated using a comprehensive neurological and neuropsychological protocol and were assessed with the FCSRT and LASSI-L. FDG-PET was acquired concomitantly and used for classification of patients as AD or non-AD according to brain metabolism using both visual and semi-quantitative methods. Results: LASSI-L scores allowed a better classification of patients as AD/non-AD in comparison to FCSRT. Logistic regression analysis showed delayed recall and failure to recovery from proactive semantic interference from LASSI-L as independent statistically significant predictors, obtaining an area under the curve of 0.894. This area under the curve provided a better discrimination than the best FCSRT score (total delayed recall, area under the curve 0.708, p = 0.029). Conclusions: The LASSI-L, a cognitive stress test, was superior to FCSRT in the prediction of AD features on FDG-PET. This emphasizes the possibility to advance toward an earlier diagnosis of AD from a clinical perspective.

Original languageEnglish (US)
Pages (from-to)103-111
Number of pages9
JournalJournal of Alzheimer's Disease
Volume61
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Semantics
Alzheimer Disease
Learning
Positron-Emission Tomography
Area Under Curve
Early Diagnosis
Prodromal Symptoms
Fluorodeoxyglucose F18
Exercise Test
Logistic Models
Regression Analysis
Brain

Keywords

  • Alzheimer's disease
  • early detection
  • memory
  • mild cognitive impairment
  • neuropsychological assessment
  • positron emission tomography

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Matias-Guiu, J. A., Cabrera-Martín, M. N., Curiel Cid, R., Valles-Salgado, M., Rognoni, T., Moreno-Ramos, T., ... Matías-Guiu, J. (2017). Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. Journal of Alzheimer's Disease, 61(1), 103-111. https://doi.org/10.3233/JAD-170604

Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. / Matias-Guiu, Jordi A.; Cabrera-Martín, María Nieves; Curiel Cid, Rosie; Valles-Salgado, María; Rognoni, Teresa; Moreno-Ramos, Teresa; Carreras, José Luis; Loewenstein, David; Matías-Guiu, Jorge.

In: Journal of Alzheimer's Disease, Vol. 61, No. 1, 01.01.2017, p. 103-111.

Research output: Contribution to journalArticle

Matias-Guiu, JA, Cabrera-Martín, MN, Curiel Cid, R, Valles-Salgado, M, Rognoni, T, Moreno-Ramos, T, Carreras, JL, Loewenstein, D & Matías-Guiu, J 2017, 'Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 103-111. https://doi.org/10.3233/JAD-170604
Matias-Guiu JA, Cabrera-Martín MN, Curiel Cid R, Valles-Salgado M, Rognoni T, Moreno-Ramos T et al. Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. Journal of Alzheimer's Disease. 2017 Jan 1;61(1):103-111. https://doi.org/10.3233/JAD-170604
Matias-Guiu, Jordi A. ; Cabrera-Martín, María Nieves ; Curiel Cid, Rosie ; Valles-Salgado, María ; Rognoni, Teresa ; Moreno-Ramos, Teresa ; Carreras, José Luis ; Loewenstein, David ; Matías-Guiu, Jorge. / Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2017 ; Vol. 61, No. 1. pp. 103-111.
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AU - Valles-Salgado, María

AU - Rognoni, Teresa

AU - Moreno-Ramos, Teresa

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