Comparing the effects of antidepressants: Consensus guidelines for evaluating quantitative reviews of antidepressant efficacy

Jeffery A. Lieberman, Joel Greenhouse, Robert M. Hamer, K. Ranga Krishnan, Charles B. Nemeroff, David V. Sheehan, Michael E. Thase, Martin B. Keller

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

With increasing numbers of treatment options available for patients with major depression over the last decade and the growing body of evidence describing their efficacy and safety, clinicians often find it difficult to determine the best and most appropriate evidence-based treatment for each patient. Systematic reviews utilizing statistical methods that synthesize and evaluate data from a number of studies have become increasingly more available over the past decade. We review major findings and lessons learned from salient examples of quantitative analyses of antidepressant research and provide recommendations for meta-analysts, journal and grant reviewers, and research 'consumers' (ie, clinicians) for conducting, reporting, and evaluating such analyses.

Original languageEnglish (US)
Pages (from-to)445-460
Number of pages16
JournalNeuropsychopharmacology
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Keywords

  • Antidepressive agents
  • Evidence-based medicine
  • Meta-analysis
  • Quality control
  • Randomized controlled trials
  • Research design

ASJC Scopus subject areas

  • Pharmacology

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    Lieberman, J. A., Greenhouse, J., Hamer, R. M., Krishnan, K. R., Nemeroff, C. B., Sheehan, D. V., Thase, M. E., & Keller, M. B. (2005). Comparing the effects of antidepressants: Consensus guidelines for evaluating quantitative reviews of antidepressant efficacy. Neuropsychopharmacology, 30(3), 445-460. https://doi.org/10.1038/sj.npp.1300571