Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression

Dilraj S. Grewal, Mitra Sehi, David Greenfield, C. D. Quinn, Krishna Kishor, J. S. Schuman, R. J. Noecker, H. Ishikawa, G. Wollstein, R. A. Billonick, L. Kagemann, D. Huang, R. Varma, V. Chopra, B. Francis, F. Memarzadeh, K. L. Lu, O. Tan, S. R. Sadda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: This prospective analysis was designed to examine the rate of RNFL loss using scanning laser polarimetry (GDx enhanced corneal compensation (GDxECC)) in progressing versus non-progressing eyes using various methods to define functional progression. Methods: Glaucoma suspect and glaucomatous eyes with ≥3 years of follow-up participating in the Advanced Imaging for Glaucoma Study were enrolled. All eyes underwent standard automated perimetry (SAP) and GDxECC imaging every 6 months. The annual rate of RNFL loss with GDxECC was calculated using linear regression analysis. Functional progression was determined using the Early Manifest Glaucoma Trial (EMGT) criterion, SAP Visual Field Index (VFI) and Progressor software. Results: Fifty-three eyes (30 glaucoma suspect, 23 glaucoma) of 53 patients (mean age 64.5±10.7 years, range 42-79) were enrolled. Eighteen eyes (40%) demonstrated SAP progression during the follow-up period using the Progressor criterion, 10 eyes (18.9%) using the VFI criterion, and 3 eyes (5.7%) using the EMGT criterion. The annual rate (mm/year) of mean RNFL loss was significantly greater (p<0.05) in progressing versus non-progressing eyes using Progressor (-1.24±0.99 vs -0.18±0.49), EMGT (-1.95±0.99 vs -0.46±0.78) and VFI (-1.11±0.64 vs -0.41±0.85) criteria. Conclusion: Despite differences in the criteria used to judge functional progression, progressing eyes have a significantly greater rate of RNFL loss measured using GDxECC as compared with non-progressing eyes.

Original languageEnglish
Pages (from-to)1122-1127
Number of pages6
JournalBritish Journal of Ophthalmology
Volume95
Issue number8
DOIs
StatePublished - Aug 1 2011

Fingerprint

Visual Fields
Nerve Fibers
Glaucoma
Visual Field Tests
Ocular Hypertension
Scanning Laser Polarimetry
Linear Models
Software
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression. / Grewal, Dilraj S.; Sehi, Mitra; Greenfield, David; Quinn, C. D.; Kishor, Krishna; Schuman, J. S.; Noecker, R. J.; Ishikawa, H.; Wollstein, G.; Billonick, R. A.; Kagemann, L.; Huang, D.; Varma, R.; Chopra, V.; Francis, B.; Memarzadeh, F.; Lu, K. L.; Tan, O.; Sadda, S. R.

In: British Journal of Ophthalmology, Vol. 95, No. 8, 01.08.2011, p. 1122-1127.

Research output: Contribution to journalArticle

Grewal, DS, Sehi, M, Greenfield, D, Quinn, CD, Kishor, K, Schuman, JS, Noecker, RJ, Ishikawa, H, Wollstein, G, Billonick, RA, Kagemann, L, Huang, D, Varma, R, Chopra, V, Francis, B, Memarzadeh, F, Lu, KL, Tan, O & Sadda, SR 2011, 'Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression', British Journal of Ophthalmology, vol. 95, no. 8, pp. 1122-1127. https://doi.org/10.1136/bjo.2010.183483
Grewal, Dilraj S. ; Sehi, Mitra ; Greenfield, David ; Quinn, C. D. ; Kishor, Krishna ; Schuman, J. S. ; Noecker, R. J. ; Ishikawa, H. ; Wollstein, G. ; Billonick, R. A. ; Kagemann, L. ; Huang, D. ; Varma, R. ; Chopra, V. ; Francis, B. ; Memarzadeh, F. ; Lu, K. L. ; Tan, O. ; Sadda, S. R. / Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression. In: British Journal of Ophthalmology. 2011 ; Vol. 95, No. 8. pp. 1122-1127.
@article{91b31b1dd1b54bd89e6154c2f6190bd1,
title = "Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression",
abstract = "Background: This prospective analysis was designed to examine the rate of RNFL loss using scanning laser polarimetry (GDx enhanced corneal compensation (GDxECC)) in progressing versus non-progressing eyes using various methods to define functional progression. Methods: Glaucoma suspect and glaucomatous eyes with ≥3 years of follow-up participating in the Advanced Imaging for Glaucoma Study were enrolled. All eyes underwent standard automated perimetry (SAP) and GDxECC imaging every 6 months. The annual rate of RNFL loss with GDxECC was calculated using linear regression analysis. Functional progression was determined using the Early Manifest Glaucoma Trial (EMGT) criterion, SAP Visual Field Index (VFI) and Progressor software. Results: Fifty-three eyes (30 glaucoma suspect, 23 glaucoma) of 53 patients (mean age 64.5±10.7 years, range 42-79) were enrolled. Eighteen eyes (40{\%}) demonstrated SAP progression during the follow-up period using the Progressor criterion, 10 eyes (18.9{\%}) using the VFI criterion, and 3 eyes (5.7{\%}) using the EMGT criterion. The annual rate (mm/year) of mean RNFL loss was significantly greater (p<0.05) in progressing versus non-progressing eyes using Progressor (-1.24±0.99 vs -0.18±0.49), EMGT (-1.95±0.99 vs -0.46±0.78) and VFI (-1.11±0.64 vs -0.41±0.85) criteria. Conclusion: Despite differences in the criteria used to judge functional progression, progressing eyes have a significantly greater rate of RNFL loss measured using GDxECC as compared with non-progressing eyes.",
author = "Grewal, {Dilraj S.} and Mitra Sehi and David Greenfield and Quinn, {C. D.} and Krishna Kishor and Schuman, {J. S.} and Noecker, {R. J.} and H. Ishikawa and G. Wollstein and Billonick, {R. A.} and L. Kagemann and D. Huang and R. Varma and V. Chopra and B. Francis and F. Memarzadeh and Lu, {K. L.} and O. Tan and Sadda, {S. R.}",
year = "2011",
month = "8",
day = "1",
doi = "10.1136/bjo.2010.183483",
language = "English",
volume = "95",
pages = "1122--1127",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression

AU - Grewal, Dilraj S.

AU - Sehi, Mitra

AU - Greenfield, David

AU - Quinn, C. D.

AU - Kishor, Krishna

AU - Schuman, J. S.

AU - Noecker, R. J.

AU - Ishikawa, H.

AU - Wollstein, G.

AU - Billonick, R. A.

AU - Kagemann, L.

AU - Huang, D.

AU - Varma, R.

AU - Chopra, V.

AU - Francis, B.

AU - Memarzadeh, F.

AU - Lu, K. L.

AU - Tan, O.

AU - Sadda, S. R.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Background: This prospective analysis was designed to examine the rate of RNFL loss using scanning laser polarimetry (GDx enhanced corneal compensation (GDxECC)) in progressing versus non-progressing eyes using various methods to define functional progression. Methods: Glaucoma suspect and glaucomatous eyes with ≥3 years of follow-up participating in the Advanced Imaging for Glaucoma Study were enrolled. All eyes underwent standard automated perimetry (SAP) and GDxECC imaging every 6 months. The annual rate of RNFL loss with GDxECC was calculated using linear regression analysis. Functional progression was determined using the Early Manifest Glaucoma Trial (EMGT) criterion, SAP Visual Field Index (VFI) and Progressor software. Results: Fifty-three eyes (30 glaucoma suspect, 23 glaucoma) of 53 patients (mean age 64.5±10.7 years, range 42-79) were enrolled. Eighteen eyes (40%) demonstrated SAP progression during the follow-up period using the Progressor criterion, 10 eyes (18.9%) using the VFI criterion, and 3 eyes (5.7%) using the EMGT criterion. The annual rate (mm/year) of mean RNFL loss was significantly greater (p<0.05) in progressing versus non-progressing eyes using Progressor (-1.24±0.99 vs -0.18±0.49), EMGT (-1.95±0.99 vs -0.46±0.78) and VFI (-1.11±0.64 vs -0.41±0.85) criteria. Conclusion: Despite differences in the criteria used to judge functional progression, progressing eyes have a significantly greater rate of RNFL loss measured using GDxECC as compared with non-progressing eyes.

AB - Background: This prospective analysis was designed to examine the rate of RNFL loss using scanning laser polarimetry (GDx enhanced corneal compensation (GDxECC)) in progressing versus non-progressing eyes using various methods to define functional progression. Methods: Glaucoma suspect and glaucomatous eyes with ≥3 years of follow-up participating in the Advanced Imaging for Glaucoma Study were enrolled. All eyes underwent standard automated perimetry (SAP) and GDxECC imaging every 6 months. The annual rate of RNFL loss with GDxECC was calculated using linear regression analysis. Functional progression was determined using the Early Manifest Glaucoma Trial (EMGT) criterion, SAP Visual Field Index (VFI) and Progressor software. Results: Fifty-three eyes (30 glaucoma suspect, 23 glaucoma) of 53 patients (mean age 64.5±10.7 years, range 42-79) were enrolled. Eighteen eyes (40%) demonstrated SAP progression during the follow-up period using the Progressor criterion, 10 eyes (18.9%) using the VFI criterion, and 3 eyes (5.7%) using the EMGT criterion. The annual rate (mm/year) of mean RNFL loss was significantly greater (p<0.05) in progressing versus non-progressing eyes using Progressor (-1.24±0.99 vs -0.18±0.49), EMGT (-1.95±0.99 vs -0.46±0.78) and VFI (-1.11±0.64 vs -0.41±0.85) criteria. Conclusion: Despite differences in the criteria used to judge functional progression, progressing eyes have a significantly greater rate of RNFL loss measured using GDxECC as compared with non-progressing eyes.

UR - http://www.scopus.com/inward/record.url?scp=79960631476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960631476&partnerID=8YFLogxK

U2 - 10.1136/bjo.2010.183483

DO - 10.1136/bjo.2010.183483

M3 - Article

VL - 95

SP - 1122

EP - 1127

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 8

ER -