Comparative Thrombogenicity of Pacemaker Leads

GEORGE M. PALATIANOS, MRINAL K. DEWANJEE, GEORGE PANOUTSOPOULOS, MANSOOR KAPADVANJWALA, STANA NOVAK, GEORGE N. SFAKIANAKIS

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Abstract

To evaluate the thrombogenicity of transvenous silicone and polyurethane pacemaker leads, 9 of 12 anesthetized Yorkshire pigs (27-32 kg) were implanted with silicone (n = 5) or polyurethane (n = 4) pacemaker leads via a femoral vein. The remaining three pigs served as controls. All 12 pigs were injected with autologous indium-111 labeled platelets (300-420 μCi) 24 hours before anesthesia induction. The pigs were monitored for 3 hours under a gamma camera. Radioactivity in blood and lead segments was measured with a gamma counter. Platelet deposits were denser on silicone leads (441.58 ± 915.0 to 2.19 ± 2.07) than on polyurethane leads (1.21 ± 1.33 to 0.27 ± 0.14) (P > 0.05). Denser platelet deposits were detected at the tip of all leads. Density of platelet deposits declined from tip to distal segments in silicone leads. The percentage of injected platelet radioactivity in the lungs of pigs with either silastic leads (12.9 ± 2.3%) or polyurethane leads (10.1 ± 2.2%) was higher than in the controls (4.6 ± 0.5%) (P < 0.05). This difference indicates thrombus formation and embolization in the lungs early after lead implantation. Thrombogenicity of polyurethane leads may be lower than that of silicone leads.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalPacing and Clinical Electrophysiology
Volume17
Issue number2
DOIs
StatePublished - Feb 1994

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Keywords

  • pacemaker leads
  • platelets
  • pulmonary embolism
  • thromboembolism
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

PALATIANOS, GEORGE. M., DEWANJEE, MRINAL. K., PANOUTSOPOULOS, GEORGE., KAPADVANJWALA, MANSOOR., NOVAK, STANA., & SFAKIANAKIS, GEORGE. N. (1994). Comparative Thrombogenicity of Pacemaker Leads. Pacing and Clinical Electrophysiology, 17(2), 141-145. https://doi.org/10.1111/j.1540-8159.1994.tb01364.x