Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma

Ming Chi Wu; Adel A Yunis

doi:10.1016/0020-711X(79)90080-6

Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma

Ming Chi Wu, Adel A Yunis

Medicine

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Abstract

1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells.

Original language	English (US)
Pages (from-to)	1001-1006
Number of pages	6
Journal	International Journal of Biochemistry
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/0020-711X(79)90080-6
State	Published - 1979

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ASJC Scopus subject areas

Biochemistry

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Wu, M. C., & Yunis, A. A. (1979). Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma. International Journal of Biochemistry, 10(12), 1001-1006. https://doi.org/10.1016/0020-711X(79)90080-6

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10.1016/0020-711X(79)90080-6