Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma

Ming Chi Wu, Adel A Yunis

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalInternational Journal of Biochemistry
Volume10
Issue number12
DOIs
StatePublished - 1979

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Plasminogen Activators
Urokinase-Type Plasminogen Activator
Cells
Amino Acids
Cell Line
Antibodies
Immunodiffusion
Rats
Breast Neoplasms
Rabbits
Pancreatic Carcinoma
Enzymes
Chemical analysis
Neoplasms
Experiments

ASJC Scopus subject areas

  • Biochemistry

Cite this

Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma. / Wu, Ming Chi; Yunis, Adel A.

In: International Journal of Biochemistry, Vol. 10, No. 12, 1979, p. 1001-1006.

Research output: Contribution to journalArticle

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