Abstract
1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1001-1006 |
| Number of pages | 6 |
| Journal | International Journal of Biochemistry |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma. / Wu, Ming Chi; Yunis, Adel A.
In: International Journal of Biochemistry, Vol. 10, No. 12, 1979, p. 1001-1006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative studies on urokinase and plasminogen activator from cultured pancreatic carcinoma
AU - Wu, Ming Chi
AU - Yunis, Adel A
PY - 1979
Y1 - 1979
N2 - 1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells.
AB - 1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells.
UR - http://www.scopus.com/inward/record.url?scp=0018668096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018668096&partnerID=8YFLogxK
U2 - 10.1016/0020-711X(79)90080-6
DO - 10.1016/0020-711X(79)90080-6
M3 - Article
C2 - 116877
AN - SCOPUS:0018668096
VL - 10
SP - 1001
EP - 1006
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 12
ER -