Comparative renal histomorphometry: A case study of oligonephropathy of prematurity

Maria M. Rodriguez, Alexander Gomez, Carolyn Abitbol, Jayanthi Chandar, Brenda Montané, Gastón Zilleruelo

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Children born with very low birth weight have a decreased nephron number. Low nephron mass is associated with adult hypertension, proteinuria, and diabetes mellitus. The histomorphometry and radial glomerular count (RGC) of a total nephrectomy from a child with renal disease associated with extreme prematurity was compared with the kidney from a full-term age-matched child of normal gestation with chronic renal failure due to focal and segmental glomerulosclerosis (FSGS) and to a child without renal disease. Bowman's space area, mesangium and mesangial tuft area were determined in 50 glomeruli of each specimen by computer-assisted morphometry. RGC was 4 in the ex-preterm child, 8 in the patient with FSGS, and 9 in normal control. The patient with FSGS had larger glomerular area expressed as square micrometers (μ m2) of Bowman's capsule, the mesangium and the mesangial tuft area measurements than the normal control and the child born preterm who subsequently developed renal failure had significantly larger Bowman's capsule and mesangium than the two controls. This case report begins to identify important pathologic findings of decreased nephron numbers and glomerulomegaly associated with preterm birth.

Original languageEnglish (US)
Pages (from-to)945-949
Number of pages5
JournalPediatric Nephrology
Issue number7
StatePublished - Jul 1 2005


  • Hypertension
  • Low birth weight
  • Neonatal renal failure
  • Nephrogenesis
  • Oligonephronia
  • Oligonephropathy

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Comparative renal histomorphometry: A case study of oligonephropathy of prematurity'. Together they form a unique fingerprint.

Cite this