Comparative in-vitro activities of apalcillin and other acylamino penicillin derivatives

T. A. Hoffman, Timothy Cleary, D. Fertel, J. C. Chan

Research output: Contribution to journalArticle

Abstract

The in vitro activities of apalcillin against 649 clinical isolates were compared with those of three other acylamino penicillins: piperacillin, mezlocillin and azlocillin. Apalcillin was comparable to piperacillin and mezlocillin against 10 species of Enterobacteriaceae, Hemophilus influenzae and gram-positive organisms. Apalcillin had a more potent action than other penicillins against Pseudomonas aeruginosa; the minimum inhibitory concentrations of apalcillin for 50% and 90% of the isolates were 2 and 32 μg/ml, respectively. The prevalence of resistance to the acylamino penicillins was high among Acinetobacter, but 75.7% were inhibited by 64 μg/ml or less of apalcillin.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume38
Issue number5
StatePublished - Dec 1 1985

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Penicillins
Mezlocillin
Piperacillin
Azlocillin
Acinetobacter
Haemophilus influenzae
Microbial Sensitivity Tests
Enterobacteriaceae
Pseudomonas aeruginosa
Inhibitory Concentration 50
In Vitro Techniques
apalcillin

ASJC Scopus subject areas

  • Medicine(all)

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Comparative in-vitro activities of apalcillin and other acylamino penicillin derivatives. / Hoffman, T. A.; Cleary, Timothy; Fertel, D.; Chan, J. C.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 38, No. 5, 01.12.1985, p. 772-777.

Research output: Contribution to journalArticle

Hoffman, T. A. ; Cleary, Timothy ; Fertel, D. ; Chan, J. C. / Comparative in-vitro activities of apalcillin and other acylamino penicillin derivatives. In: Current Therapeutic Research - Clinical and Experimental. 1985 ; Vol. 38, No. 5. pp. 772-777.
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