Comparative in-vitro activities of apalcillin and other acylamino penicillin derivatives

T. A. Hoffman, T. J. Cleary, D. Fertel, J. C. Chan

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Abstract

The in vitro activities of apalcillin against 649 clinical isolates were compared with those of three other acylamino penicillins: piperacillin, mezlocillin and azlocillin. Apalcillin was comparable to piperacillin and mezlocillin against 10 species of Enterobacteriaceae, Hemophilus influenzae and gram-positive organisms. Apalcillin had a more potent action than other penicillins against Pseudomonas aeruginosa; the minimum inhibitory concentrations of apalcillin for 50% and 90% of the isolates were 2 and 32 μg/ml, respectively. The prevalence of resistance to the acylamino penicillins was high among Acinetobacter, but 75.7% were inhibited by 64 μg/ml or less of apalcillin.

Original languageEnglish (US)
Pages (from-to)772-777
Number of pages6
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume38
Issue number5
StatePublished - Jan 1 1985

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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