The in vitro activities of apalcillin against 649 clinical isolates were compared with those of three other acylamino penicillins: piperacillin, mezlocillin and azlocillin. Apalcillin was comparable to piperacillin and mezlocillin against 10 species of Enterobacteriaceae, Hemophilus influenzae and gram-positive organisms. Apalcillin had a more potent action than other penicillins against Pseudomonas aeruginosa; the minimum inhibitory concentrations of apalcillin for 50% and 90% of the isolates were 2 and 32 μg/ml, respectively. The prevalence of resistance to the acylamino penicillins was high among Acinetobacter, but 75.7% were inhibited by 64 μg/ml or less of apalcillin.
|Original language||English (US)|
|Number of pages||6|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|State||Published - Jan 1 1985|
ASJC Scopus subject areas
- Pharmacology (medical)