Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction

Claudia P. Rojas, Arnel K. Urbiztondo, Jocelyn H. Bruce, Maria M. Rodriguez

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.

Original languageEnglish (US)
Pages (from-to)209-219
Number of pages11
JournalFetal and Pediatric Pathology
Volume30
Issue number4
DOIs
StatePublished - Jul 14 2011

Keywords

  • Autopsies
  • Developmental pathology
  • Immunohistochemistry
  • Nonobstructive multicystic dysplastic kidney
  • Obstructive multicystic dysplastic kidney
  • Transcription growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

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