Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction

Claudia P. Rojas; Arnel K. Urbiztondo; Jocelyn H. Bruce; Maria M. Rodriguez

doi:10.3109/15513815.2011.572960

Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction

Claudia P. Rojas, Arnel K. Urbiztondo, Jocelyn H. Bruce, Maria M. Rodriguez

Pathology

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.

Original language	English (US)
Pages (from-to)	209-219
Number of pages	11
Journal	Fetal and Pediatric Pathology
Volume	30
Issue number	4
DOIs	https://doi.org/10.3109/15513815.2011.572960
State	Published - Jul 14 2011

Keywords

Autopsies
Developmental pathology
Immunohistochemistry
Nonobstructive multicystic dysplastic kidney
Obstructive multicystic dysplastic kidney
Transcription growth factor

ASJC Scopus subject areas

Pathology and Forensic Medicine
Pediatrics, Perinatology, and Child Health

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Rojas, C. P., Urbiztondo, A. K., Bruce, J. H., & Rodriguez, M. M. (2011). Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction. Fetal and Pediatric Pathology, 30(4), 209-219. https://doi.org/10.3109/15513815.2011.572960

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abstract = "Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.",

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