Abstract
Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 209-219 |
| Number of pages | 11 |
| Journal | Fetal and Pediatric Pathology |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 14 2011 |
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Keywords
- Autopsies
- Developmental pathology
- Immunohistochemistry
- Nonobstructive multicystic dysplastic kidney
- Obstructive multicystic dysplastic kidney
- Transcription growth factor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pediatrics, Perinatology, and Child Health
Cite this
Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction. / Rojas, Claudia P.; Urbiztondo, Arnel K.; Bruce, Jocelyn H.; Rodriguez, Maria.
In: Fetal and Pediatric Pathology, Vol. 30, No. 4, 14.07.2011, p. 209-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction
AU - Rojas, Claudia P.
AU - Urbiztondo, Arnel K.
AU - Bruce, Jocelyn H.
AU - Rodriguez, Maria
PY - 2011/7/14
Y1 - 2011/7/14
N2 - Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.
AB - Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β? was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β?-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β? and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β?-catenin in obstructive versus nonobstructive dysplasia.
KW - Autopsies
KW - Developmental pathology
KW - Immunohistochemistry
KW - Nonobstructive multicystic dysplastic kidney
KW - Obstructive multicystic dysplastic kidney
KW - Transcription growth factor
UR - http://www.scopus.com/inward/record.url?scp=79959941947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959941947&partnerID=8YFLogxK
U2 - 10.3109/15513815.2011.572960
DO - 10.3109/15513815.2011.572960
M3 - Article
C2 - 21689023
AN - SCOPUS:79959941947
VL - 30
SP - 209
EP - 219
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
SN - 1551-3815
IS - 4
ER -