Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia

R. A. Dominguez, B. J. Goldstein, A. F. Jacobson, R. M. Steinbook

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The efficacy and safety of estazolam, an investigational triazolobenzodiazepine, and flurazepam were compared in 65 insomniac outpatients. Patients completed sleep questionnaires each morning. Global evaluations demonstrated that both treatments were significantly superior to placebo. However, estazolam was preferred over flurazepam in a global rating that reflected how well rested and refreshed the subjects felt on arising. Improvement in complaints of difficulty in going to sleep showed only a trend toward significance favoring estazolam and flurazepam over placebo. Residual daytime drowsiness and fatigue accounted for approximately 70% of all side effects with both active treatments. Significantly more side effects occurred with flurazepam than with estazolam. Flurazepam-treated patients had a significantly more severe rating of adverse reactions than did placebo-treated patients.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalJournal of Clinical Psychiatry
Issue number7
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Psychiatry and Mental health


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