TY - JOUR
T1 - Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension
AU - Moser, Marvin
AU - Lunn, John
AU - Materson, Barry J.
PY - 1985/12/6
Y1 - 1985/12/6
N2 - The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
AB - The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
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U2 - 10.1016/0002-9149(85)90553-3
DO - 10.1016/0002-9149(85)90553-3
M3 - Article
C2 - 4072939
AN - SCOPUS:0022396168
VL - 56
SP - H101-H104
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 16
ER -