Abstract
The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
| Original language | English |
|---|---|
| Journal | The American journal of cardiology |
| Volume | 56 |
| Issue number | 16 |
| DOIs | |
| State | Published - Dec 6 1985 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension. / Moser, Marvin; Lunn, John; Materson, Barry J.
In: The American journal of cardiology, Vol. 56, No. 16, 06.12.1985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension
AU - Moser, Marvin
AU - Lunn, John
AU - Materson, Barry J
PY - 1985/12/6
Y1 - 1985/12/6
N2 - The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
AB - The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
UR - http://www.scopus.com/inward/record.url?scp=0022396168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022396168&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(85)90553-3
DO - 10.1016/0002-9149(85)90553-3
M3 - Article
VL - 56
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 16
ER -