Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension

Marvin Moser, John Lunn, Barry J Materson

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40 Citations (Scopus)

Abstract

The blood pressure-lowering effects of a calciumentry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34 -18 mm Hg for diltiazem and -29 -21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.

Original languageEnglish
JournalThe American journal of cardiology
Volume56
Issue number16
DOIs
StatePublished - Dec 6 1985

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Hydrochlorothiazide
Diltiazem
Blood Pressure
Hypertension
Sodium Chloride Symporter Inhibitors
Pharmaceutical Preparations
Antihypertensive Agents
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension. / Moser, Marvin; Lunn, John; Materson, Barry J.

In: The American journal of cardiology, Vol. 56, No. 16, 06.12.1985.

Research output: Contribution to journalArticle

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