Comparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro

A. Krishan, K. Dutt, M. Israel, R. Ganapathi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

N-Trifluoroacetyladriamycin-14-valerate differs from Adriamycin in its rapid intracellular transport and lack of fluorescent binding to nuclei or chromosomes. Both of these anthracyclines cause inhibition in the incorporation of labeled precursors into nucleic acids, extensive chromosomal damage, and arrest of cell cycle transverse in G2. In human lymphoid cells, N-trifluoroacetyladriamycin-14-valerate, unlike Adriamycin, does not show cell cycle phase-specific or proliferation-related cytotoxic effects. In an L1210 soft-agar assay, both Adriamycin and N-trifluoroacetyladriamycin-14-valerate show no enhanced sensitivity of mid-S-phase cells to their cytotoxic action.

Original languageEnglish
Pages (from-to)2745-2750
Number of pages6
JournalCancer Research
Volume41
Issue number7
StatePublished - Jan 1 1981
Externally publishedYes

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valrubicin
Doxorubicin
Nucleic Acid Precursors
Anthracyclines
Cell Cycle Checkpoints
S Phase
Agar
Cell Cycle
Chromosomes
Lymphocytes
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Comparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro. / Krishan, A.; Dutt, K.; Israel, M.; Ganapathi, R.

In: Cancer Research, Vol. 41, No. 7, 01.01.1981, p. 2745-2750.

Research output: Contribution to journalArticle

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