Comparative effects of adriamycin and n-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro

Awtar Krishan, Mervyn Israel

Research output: Contribution to journalArticle

41 Scopus citations


N-Trifluoroacetyladriamycin-14-valerate differs from Adriamycin in its rapid intracellular transport and lack of fluorescent binding to nuclei or chromosomes. Both of these anthracyclines cause inhibition in the incorporation of labeled precursors into nucleic acids, extensive chromosomal damage, and arrest of cell cycle transverse in G2. In human lymphoid cells, N-trifluoroacetyladriamycin-14-valerate, unlike Adriamycin, does not show cell cycle phase-specific or proliferation-related cytotoxic effects. In an L1210 soft-agar assay, both Adriamycin and N-trifluoroacetyladriamycin-14-valerate show no enhanced sensitivity of mid-S-phase cells to their cytotoxic action.

Original languageEnglish (US)
Pages (from-to)2745-2750
Number of pages6
JournalCancer Research
Issue number7
StatePublished - Jul 1 1981


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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