Comparative effect of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells

Adel A Yunis, D. R. Manyan, G. K. Arimura

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Thiamphenicol, a chloramphenicol analogue with substitution of the p-nitro group by a methylsulfonyl (CH3-SO2-) group is used extensively in Europe as a chloramphenicol substitute. It has been stated that thiamphenicol produces reversible bone marrow suppression but has not been associated with aplastic anemia. A comparative metabolic study indicates that both chloramphenicol and thiamphenicol are potent inhibitors of mitochondrial protein synthesis. However, in contrast to chloramphenicol which at high concentrations inhibits DNA synthesis, thiamphenicol had little effect on DNA synthesis.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalThe Journal of laboratory and clinical medicine
Volume81
Issue number5
StatePublished - 1973

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ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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