Comparative effect of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells

A. A. Yunis; D. R. Manyan; G. K. Arimura

Comparative effect of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells

A. A. Yunis, D. R. Manyan, G. K. Arimura

Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Thiamphenicol, a chloramphenicol analogue with substitution of the p-nitro group by a methylsulfonyl (CH₃-SO₂-) group is used extensively in Europe as a chloramphenicol substitute. It has been stated that thiamphenicol produces reversible bone marrow suppression but has not been associated with aplastic anemia. A comparative metabolic study indicates that both chloramphenicol and thiamphenicol are potent inhibitors of mitochondrial protein synthesis. However, in contrast to chloramphenicol which at high concentrations inhibits DNA synthesis, thiamphenicol had little effect on DNA synthesis.

Original language	English (US)
Pages (from-to)	713-718
Number of pages	6
Journal	The Journal of Laboratory and Clinical Medicine
Volume	81
Issue number	5
State	Published - May 1973

ASJC Scopus subject areas

Pathology and Forensic Medicine

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N2 - Thiamphenicol, a chloramphenicol analogue with substitution of the p-nitro group by a methylsulfonyl (CH3-SO2-) group is used extensively in Europe as a chloramphenicol substitute. It has been stated that thiamphenicol produces reversible bone marrow suppression but has not been associated with aplastic anemia. A comparative metabolic study indicates that both chloramphenicol and thiamphenicol are potent inhibitors of mitochondrial protein synthesis. However, in contrast to chloramphenicol which at high concentrations inhibits DNA synthesis, thiamphenicol had little effect on DNA synthesis.

AB - Thiamphenicol, a chloramphenicol analogue with substitution of the p-nitro group by a methylsulfonyl (CH3-SO2-) group is used extensively in Europe as a chloramphenicol substitute. It has been stated that thiamphenicol produces reversible bone marrow suppression but has not been associated with aplastic anemia. A comparative metabolic study indicates that both chloramphenicol and thiamphenicol are potent inhibitors of mitochondrial protein synthesis. However, in contrast to chloramphenicol which at high concentrations inhibits DNA synthesis, thiamphenicol had little effect on DNA synthesis.

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