Abstract
Thiamphenicol, a chloramphenicol analogue with substitution of the p-nitro group by a methylsulfonyl (CH3-SO2-) group is used extensively in Europe as a chloramphenicol substitute. It has been stated that thiamphenicol produces reversible bone marrow suppression but has not been associated with aplastic anemia. A comparative metabolic study indicates that both chloramphenicol and thiamphenicol are potent inhibitors of mitochondrial protein synthesis. However, in contrast to chloramphenicol which at high concentrations inhibits DNA synthesis, thiamphenicol had little effect on DNA synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 713-718 |
| Number of pages | 6 |
| Journal | The Journal of Laboratory and Clinical Medicine |
| Volume | 81 |
| Issue number | 5 |
| State | Published - May 1973 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Yunis, A. A., Manyan, D. R., & Arimura, G. K. (1973). Comparative effect of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells. The Journal of Laboratory and Clinical Medicine, 81(5), 713-718.