Comparative biology of natural and experimental SIVmac infection in macaque monkeys: A review

N. W. King, L. V. Chalifoux, D. J. Ringler, M. S. Wyand, P. K. Sehgal, M. D. Daniel, N. L. Letvin, Ronald Charles Desrosiers, B. J. Blake, R. D. Hunt

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Abstract

Epidemiologic and clinicopathologic data from 11 macaques with naturally acquired SIV infection - 10 of which have died - were compared with those from 34 rhesus monkeys that have died of experimental SIVmac infection. Several differences, including gender affected, age at time of death, and the occurrence of certain opportunistic infections, could be explained by the experimental design; others remained unexplained. The most striking difference was the 14% incidence of meningoencephalomyelitis in the experimental group and its absence in naturally SIV-infected animals.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalJournal of Medical Primatology
Volume19
Issue number2
StatePublished - 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

King, N. W., Chalifoux, L. V., Ringler, D. J., Wyand, M. S., Sehgal, P. K., Daniel, M. D., Letvin, N. L., Desrosiers, R. C., Blake, B. J., & Hunt, R. D. (1990). Comparative biology of natural and experimental SIVmac infection in macaque monkeys: A review. Journal of Medical Primatology, 19(2), 109-118.