Comorbidity: A multidimensional approach

Enrico Capobianco, Pietro Lio'

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Comorbidity represents an extremely complex domain of research. An individual entity, the patient, is the center of gravity of a system characterized by multiple, complex, and interrelated conditions, disorders, or diseases. Such complexity is influenced by uncertainty that is difficult to decipher and is proportional to the number of associated morbidities. Computational scientists usually provide meta-analysis studies aimed at integrating various types of evidence, but in our opinion they may help reformulate comorbidity by emphasizing, in particular, two aspects: (i) a systems approach, which allows for an ensemble view of comorbidity, and offers a model representation generalizable to multimorbidity; and (ii) a dynamic network inference approach, which is indicated for the analysis of links among morbidities and evaluation of risk. Notably, the main question remains whether such instruments suggest a shift of paradigm providing prospective impact on medical practice. We have identified in the simultaneous consideration of multiple dimensions linked to comorbidity complexity the rationale for such translation.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalTrends in Molecular Medicine
Volume19
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • Clustering
  • Comorbidity
  • Dynamic mapping
  • Inference
  • Multidimensionality
  • Patient disease network

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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