Comorbid depression and anxiety effects on pregnancy and neonatal outcome

Tiffany M Field, Miguel A Diego, Maria Hernandez-Reif, Barbara Figueiredo, Osvelia Deeds, Angela Ascencio, Saul Schanberg, Cynthia Kuhn

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

The effects of comorbid depression and anxiety were compared to the effects of depression alone and anxiety alone on pregnancy mood states and biochemistry and on neonatal outcomes in a large multi-ethnic sample. At the prenatal period the comorbid and depressed groups had higher scores than the other groups on the depression measure. But, the comorbid group had higher anxiety, anger and daily hassles scores than the other groups, and they had lower dopamine levels. As compared to the non-depressed group, they also reported more sleep disturbances and relationship problems. The comorbid group also experienced a greater incidence of prematurity than the depressed, the high anxiety and the non-depressed groups. Although the comorbid and anxiety groups were lower birthweight than the non-depressed and depressed groups, the comorbid group did not differ from the depressed and anxiety groups on birth length. The neonates of the comorbid and depressed groups had higher cortisol and norepinephrine and lower dopamine and serotonin levels than the neonates of the anxiety and non-depressed groups as well as greater relative right frontal EEG. These data suggest that for some measures comorbidity of depression and anxiety is the worst condition (e.g., incidence of prematurity), while for others, comorbidity is no more impactful than depression alone.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalInfant Behavior and Development
Volume33
Issue number1
DOIs
StatePublished - Feb 1 2010

Fingerprint

Pregnancy Outcome
Anxiety
Depression
Comorbidity
Dopamine
Incidence
Anger
Biochemistry
Hydrocortisone
Electroencephalography
Serotonin
Norepinephrine
Sleep
Parturition
Pregnancy

Keywords

  • Anxiety
  • Comorbid depression
  • Neonatal outcome
  • Pregnancy

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Comorbid depression and anxiety effects on pregnancy and neonatal outcome. / Field, Tiffany M; Diego, Miguel A; Hernandez-Reif, Maria; Figueiredo, Barbara; Deeds, Osvelia; Ascencio, Angela; Schanberg, Saul; Kuhn, Cynthia.

In: Infant Behavior and Development, Vol. 33, No. 1, 01.02.2010, p. 23-29.

Research output: Contribution to journalArticle

Field, TM, Diego, MA, Hernandez-Reif, M, Figueiredo, B, Deeds, O, Ascencio, A, Schanberg, S & Kuhn, C 2010, 'Comorbid depression and anxiety effects on pregnancy and neonatal outcome', Infant Behavior and Development, vol. 33, no. 1, pp. 23-29. https://doi.org/10.1016/j.infbeh.2009.10.004
Field, Tiffany M ; Diego, Miguel A ; Hernandez-Reif, Maria ; Figueiredo, Barbara ; Deeds, Osvelia ; Ascencio, Angela ; Schanberg, Saul ; Kuhn, Cynthia. / Comorbid depression and anxiety effects on pregnancy and neonatal outcome. In: Infant Behavior and Development. 2010 ; Vol. 33, No. 1. pp. 23-29.
@article{6f64ccf26ecd41849ec55aa3139740cb,
title = "Comorbid depression and anxiety effects on pregnancy and neonatal outcome",
abstract = "The effects of comorbid depression and anxiety were compared to the effects of depression alone and anxiety alone on pregnancy mood states and biochemistry and on neonatal outcomes in a large multi-ethnic sample. At the prenatal period the comorbid and depressed groups had higher scores than the other groups on the depression measure. But, the comorbid group had higher anxiety, anger and daily hassles scores than the other groups, and they had lower dopamine levels. As compared to the non-depressed group, they also reported more sleep disturbances and relationship problems. The comorbid group also experienced a greater incidence of prematurity than the depressed, the high anxiety and the non-depressed groups. Although the comorbid and anxiety groups were lower birthweight than the non-depressed and depressed groups, the comorbid group did not differ from the depressed and anxiety groups on birth length. The neonates of the comorbid and depressed groups had higher cortisol and norepinephrine and lower dopamine and serotonin levels than the neonates of the anxiety and non-depressed groups as well as greater relative right frontal EEG. These data suggest that for some measures comorbidity of depression and anxiety is the worst condition (e.g., incidence of prematurity), while for others, comorbidity is no more impactful than depression alone.",
keywords = "Anxiety, Comorbid depression, Neonatal outcome, Pregnancy",
author = "Field, {Tiffany M} and Diego, {Miguel A} and Maria Hernandez-Reif and Barbara Figueiredo and Osvelia Deeds and Angela Ascencio and Saul Schanberg and Cynthia Kuhn",
year = "2010",
month = "2",
day = "1",
doi = "10.1016/j.infbeh.2009.10.004",
language = "English",
volume = "33",
pages = "23--29",
journal = "Infant Behavior and Development",
issn = "0163-6383",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Comorbid depression and anxiety effects on pregnancy and neonatal outcome

AU - Field, Tiffany M

AU - Diego, Miguel A

AU - Hernandez-Reif, Maria

AU - Figueiredo, Barbara

AU - Deeds, Osvelia

AU - Ascencio, Angela

AU - Schanberg, Saul

AU - Kuhn, Cynthia

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The effects of comorbid depression and anxiety were compared to the effects of depression alone and anxiety alone on pregnancy mood states and biochemistry and on neonatal outcomes in a large multi-ethnic sample. At the prenatal period the comorbid and depressed groups had higher scores than the other groups on the depression measure. But, the comorbid group had higher anxiety, anger and daily hassles scores than the other groups, and they had lower dopamine levels. As compared to the non-depressed group, they also reported more sleep disturbances and relationship problems. The comorbid group also experienced a greater incidence of prematurity than the depressed, the high anxiety and the non-depressed groups. Although the comorbid and anxiety groups were lower birthweight than the non-depressed and depressed groups, the comorbid group did not differ from the depressed and anxiety groups on birth length. The neonates of the comorbid and depressed groups had higher cortisol and norepinephrine and lower dopamine and serotonin levels than the neonates of the anxiety and non-depressed groups as well as greater relative right frontal EEG. These data suggest that for some measures comorbidity of depression and anxiety is the worst condition (e.g., incidence of prematurity), while for others, comorbidity is no more impactful than depression alone.

AB - The effects of comorbid depression and anxiety were compared to the effects of depression alone and anxiety alone on pregnancy mood states and biochemistry and on neonatal outcomes in a large multi-ethnic sample. At the prenatal period the comorbid and depressed groups had higher scores than the other groups on the depression measure. But, the comorbid group had higher anxiety, anger and daily hassles scores than the other groups, and they had lower dopamine levels. As compared to the non-depressed group, they also reported more sleep disturbances and relationship problems. The comorbid group also experienced a greater incidence of prematurity than the depressed, the high anxiety and the non-depressed groups. Although the comorbid and anxiety groups were lower birthweight than the non-depressed and depressed groups, the comorbid group did not differ from the depressed and anxiety groups on birth length. The neonates of the comorbid and depressed groups had higher cortisol and norepinephrine and lower dopamine and serotonin levels than the neonates of the anxiety and non-depressed groups as well as greater relative right frontal EEG. These data suggest that for some measures comorbidity of depression and anxiety is the worst condition (e.g., incidence of prematurity), while for others, comorbidity is no more impactful than depression alone.

KW - Anxiety

KW - Comorbid depression

KW - Neonatal outcome

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=75549084807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75549084807&partnerID=8YFLogxK

U2 - 10.1016/j.infbeh.2009.10.004

DO - 10.1016/j.infbeh.2009.10.004

M3 - Article

C2 - 19945170

AN - SCOPUS:75549084807

VL - 33

SP - 23

EP - 29

JO - Infant Behavior and Development

JF - Infant Behavior and Development

SN - 0163-6383

IS - 1

ER -