Common pattern of two distinct types of colony-stimulating factor in human tissues and cultured cells

M. C. Wu, A. A. Yunis

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Conditioned media prepared from human lung, placenta, peripheral leukocytes, cultured human pancreatic carcinoma cells, and cultured cervical carcinoma cells exhibit a common pattern of two distinct colony-stimulating factors (CSF) separable by isoelectrofocusing. Type I CSF appears polydisperse on isoelectrofocusing, showing multiple peaks with an isoelectric point of 3.6-4.7 and mol wt 50,000. It has a much higher activity in mouse than in human bone marrow, and stimulates the formation of predominately macrophage colonies. Type II CSF has an isoelectric point of 5.7 and mol wt 27,000 and exhibits higher activity in human than in mouse marrow, yielding predominately granulocytic colonies.

Original languageEnglish (US)
Pages (from-to)772-775
Number of pages4
JournalJournal of Clinical Investigation
Volume65
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Medicine(all)

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