Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: The USE-IMT initiative

H. M. Den Ruijter; S. A.E. Peters; K. A. Groenewegen; T. J. Anderson; A. R. Britton; J. M. Dekker; G. Engström; M. J. Eijkemans; G. W. Evans; J. De Graaf; D. E. Grobbee; B. Hedblad; A. Hofman; S. Holewijn; A. Ikeda; M. Kavousi; K. Kitagawa; A. Kitamura; H. Koffijberg; M. A. Ikram; E. M. Lonn; M. W. Lorenz; E. B. Mathiesen; G. Nijpels; S. Okazaki; D. H. O'Leary; J. F. Polak; J. F. Price; C. Robertson; C. M. Rembold; M. Rosvall; T. Rundek; J. T. Salonen; M. Sitzer; C. D.A. Stehouwer; J. C. Witteman; K. G. Moons; M. L. Bots

doi:10.1007/s00125-013-2898-9

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: The USE-IMT initiative

H. M. Den Ruijter, S. A.E. Peters, K. A. Groenewegen, T. J. Anderson, A. R. Britton, J. M. Dekker, G. Engström, M. J. Eijkemans, G. W. Evans, J. De Graaf, D. E. Grobbee, B. Hedblad, A. Hofman, S. Holewijn, A. Ikeda, M. Kavousi, K. Kitagawa, A. Kitamura, H. Koffijberg, M. A. IkramE. M. Lonn, M. W. Lorenz, E. B. Mathiesen, G. Nijpels, S. Okazaki, D. H. O'Leary, J. F. Polak, J. F. Price, C. Robertson, C. M. Rembold, M. Rosvall, T. Rundek, J. T. Salonen, M. Sitzer, C. D.A. Stehouwer, J. C. Witteman, K. G. Moons, M. L. Bots

Neurology

Research output: Contribution to journal › Article

39 Scopus citations

Abstract

Aims/hypothesis: The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes. Methods: We performed a subanalysis among 4,220 individuals with diabetes in a large ongoing individual participant data meta-analysis involving 56,194 subjects from 17 population-based cohorts worldwide. We first refitted the risk factors of the Framingham heart risk score on the individuals without previous cardiovascular disease (baseline model) and then expanded this model with the mean common CIMT (CIMT model). The absolute 10 year risk for developing a myocardial infarction or stroke was estimated from both models. In individuals with diabetes we compared discrimination and calibration of the two models. Reclassification of individuals with diabetes was based on allocation to another cardiovascular risk category when mean common CIMT was added. Results: During a median follow-up of 8.7 years, 684 first-time cardiovascular events occurred among the population with diabetes. The C statistic was 0.67 for the Framingham model and 0.68 for the CIMT model. The absolute 10 year risk for developing a myocardial infarction or stroke was 16% in both models. There was no net reclassification improvement with the addition of mean common CIMT (1.7%; 95% CI -1.8, 3.8). There were no differences in the results between men and women. Conclusions/interpretation: There is no improvement in risk prediction in individuals with diabetes when measurement of the mean common CIMT is added to the Framingham risk score. Therefore, this measurement is not recommended for improving individual cardiovascular risk stratification in individuals with diabetes.

Original language	English (US)
Pages (from-to)	1494-1502
Number of pages	9
Journal	Diabetologia
Volume	56
Issue number	7
DOIs	https://doi.org/10.1007/s00125-013-2898-9
State	Published - Jul 1 2013

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Keywords

Atherosclerosis
Cardiovascular disease
Carotid intima-media thickness
Diabetes
Prognosis
Risk prediction

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Cite this

Den Ruijter, H. M., Peters, S. A. E., Groenewegen, K. A., Anderson, T. J., Britton, A. R., Dekker, J. M., Engström, G., Eijkemans, M. J., Evans, G. W., De Graaf, J., Grobbee, D. E., Hedblad, B., Hofman, A., Holewijn, S., Ikeda, A., Kavousi, M., Kitagawa, K., Kitamura, A., Koffijberg, H., ... Bots, M. L. (2013). Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: The USE-IMT initiative. Diabetologia, 56(7), 1494-1502. https://doi.org/10.1007/s00125-013-2898-9

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus : The USE-IMT initiative. / Den Ruijter, H. M.; Peters, S. A.E.; Groenewegen, K. A.; Anderson, T. J.; Britton, A. R.; Dekker, J. M.; Engström, G.; Eijkemans, M. J.; Evans, G. W.; De Graaf, J.; Grobbee, D. E.; Hedblad, B.; Hofman, A.; Holewijn, S.; Ikeda, A.; Kavousi, M.; Kitagawa, K.; Kitamura, A.; Koffijberg, H.; Ikram, M. A.; Lonn, E. M.; Lorenz, M. W.; Mathiesen, E. B.; Nijpels, G.; Okazaki, S.; O'Leary, D. H.; Polak, J. F.; Price, J. F.; Robertson, C.; Rembold, C. M.; Rosvall, M.; Rundek, T.; Salonen, J. T.; Sitzer, M.; Stehouwer, C. D.A.; Witteman, J. C.; Moons, K. G.; Bots, M. L.

In: Diabetologia, Vol. 56, No. 7, 01.07.2013, p. 1494-1502.

Research output: Contribution to journal › Article

Den Ruijter, HM, Peters, SAE, Groenewegen, KA, Anderson, TJ, Britton, AR, Dekker, JM, Engström, G, Eijkemans, MJ, Evans, GW, De Graaf, J, Grobbee, DE, Hedblad, B, Hofman, A, Holewijn, S, Ikeda, A, Kavousi, M, Kitagawa, K, Kitamura, A, Koffijberg, H, Ikram, MA, Lonn, EM, Lorenz, MW, Mathiesen, EB, Nijpels, G, Okazaki, S, O'Leary, DH, Polak, JF, Price, JF, Robertson, C, Rembold, CM, Rosvall, M, Rundek, T, Salonen, JT, Sitzer, M, Stehouwer, CDA, Witteman, JC, Moons, KG & Bots, ML 2013, 'Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: The USE-IMT initiative', Diabetologia, vol. 56, no. 7, pp. 1494-1502. https://doi.org/10.1007/s00125-013-2898-9

Den Ruijter, H. M. ; Peters, S. A.E. ; Groenewegen, K. A. ; Anderson, T. J. ; Britton, A. R. ; Dekker, J. M. ; Engström, G. ; Eijkemans, M. J. ; Evans, G. W. ; De Graaf, J. ; Grobbee, D. E. ; Hedblad, B. ; Hofman, A. ; Holewijn, S. ; Ikeda, A. ; Kavousi, M. ; Kitagawa, K. ; Kitamura, A. ; Koffijberg, H. ; Ikram, M. A. ; Lonn, E. M. ; Lorenz, M. W. ; Mathiesen, E. B. ; Nijpels, G. ; Okazaki, S. ; O'Leary, D. H. ; Polak, J. F. ; Price, J. F. ; Robertson, C. ; Rembold, C. M. ; Rosvall, M. ; Rundek, T. ; Salonen, J. T. ; Sitzer, M. ; Stehouwer, C. D.A. ; Witteman, J. C. ; Moons, K. G. ; Bots, M. L. / Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus : The USE-IMT initiative. In: Diabetologia. 2013 ; Vol. 56, No. 7. pp. 1494-1502.

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abstract = "Aims/hypothesis: The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes. Methods: We performed a subanalysis among 4,220 individuals with diabetes in a large ongoing individual participant data meta-analysis involving 56,194 subjects from 17 population-based cohorts worldwide. We first refitted the risk factors of the Framingham heart risk score on the individuals without previous cardiovascular disease (baseline model) and then expanded this model with the mean common CIMT (CIMT model). The absolute 10 year risk for developing a myocardial infarction or stroke was estimated from both models. In individuals with diabetes we compared discrimination and calibration of the two models. Reclassification of individuals with diabetes was based on allocation to another cardiovascular risk category when mean common CIMT was added. Results: During a median follow-up of 8.7 years, 684 first-time cardiovascular events occurred among the population with diabetes. The C statistic was 0.67 for the Framingham model and 0.68 for the CIMT model. The absolute 10 year risk for developing a myocardial infarction or stroke was 16% in both models. There was no net reclassification improvement with the addition of mean common CIMT (1.7%; 95% CI -1.8, 3.8). There were no differences in the results between men and women. Conclusions/interpretation: There is no improvement in risk prediction in individuals with diabetes when measurement of the mean common CIMT is added to the Framingham risk score. Therefore, this measurement is not recommended for improving individual cardiovascular risk stratification in individuals with diabetes.",

keywords = "Atherosclerosis, Cardiovascular disease, Carotid intima-media thickness, Diabetes, Prognosis, Risk prediction",

author = "{Den Ruijter}, {H. M.} and Peters, {S. A.E.} and Groenewegen, {K. A.} and Anderson, {T. J.} and Britton, {A. R.} and Dekker, {J. M.} and G. Engstr{\"o}m and Eijkemans, {M. J.} and Evans, {G. W.} and {De Graaf}, J. and Grobbee, {D. E.} and B. Hedblad and A. Hofman and S. Holewijn and A. Ikeda and M. Kavousi and K. Kitagawa and A. Kitamura and H. Koffijberg and Ikram, {M. A.} and Lonn, {E. M.} and Lorenz, {M. W.} and Mathiesen, {E. B.} and G. Nijpels and S. Okazaki and O'Leary, {D. H.} and Polak, {J. F.} and Price, {J. F.} and C. Robertson and Rembold, {C. M.} and M. Rosvall and T. Rundek and Salonen, {J. T.} and M. Sitzer and Stehouwer, {C. D.A.} and Witteman, {J. C.} and Moons, {K. G.} and Bots, {M. L.}",

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doi = "10.1007/s00125-013-2898-9",

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T1 - Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus

T2 - The USE-IMT initiative

AU - Den Ruijter, H. M.

AU - Peters, S. A.E.

AU - Groenewegen, K. A.

AU - Anderson, T. J.

AU - Britton, A. R.

AU - Dekker, J. M.

AU - Engström, G.

AU - Eijkemans, M. J.

AU - Evans, G. W.

AU - De Graaf, J.

AU - Grobbee, D. E.

AU - Hedblad, B.

AU - Hofman, A.

AU - Holewijn, S.

AU - Ikeda, A.

AU - Kavousi, M.

AU - Kitagawa, K.

AU - Kitamura, A.

AU - Koffijberg, H.

AU - Ikram, M. A.

AU - Lonn, E. M.

AU - Lorenz, M. W.

AU - Mathiesen, E. B.

AU - Nijpels, G.

AU - Okazaki, S.

AU - O'Leary, D. H.

AU - Polak, J. F.

AU - Price, J. F.

AU - Robertson, C.

AU - Rembold, C. M.

AU - Rosvall, M.

AU - Rundek, T.

AU - Salonen, J. T.

AU - Sitzer, M.

AU - Stehouwer, C. D.A.

AU - Witteman, J. C.

AU - Moons, K. G.

AU - Bots, M. L.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Aims/hypothesis: The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes. Methods: We performed a subanalysis among 4,220 individuals with diabetes in a large ongoing individual participant data meta-analysis involving 56,194 subjects from 17 population-based cohorts worldwide. We first refitted the risk factors of the Framingham heart risk score on the individuals without previous cardiovascular disease (baseline model) and then expanded this model with the mean common CIMT (CIMT model). The absolute 10 year risk for developing a myocardial infarction or stroke was estimated from both models. In individuals with diabetes we compared discrimination and calibration of the two models. Reclassification of individuals with diabetes was based on allocation to another cardiovascular risk category when mean common CIMT was added. Results: During a median follow-up of 8.7 years, 684 first-time cardiovascular events occurred among the population with diabetes. The C statistic was 0.67 for the Framingham model and 0.68 for the CIMT model. The absolute 10 year risk for developing a myocardial infarction or stroke was 16% in both models. There was no net reclassification improvement with the addition of mean common CIMT (1.7%; 95% CI -1.8, 3.8). There were no differences in the results between men and women. Conclusions/interpretation: There is no improvement in risk prediction in individuals with diabetes when measurement of the mean common CIMT is added to the Framingham risk score. Therefore, this measurement is not recommended for improving individual cardiovascular risk stratification in individuals with diabetes.

AB - Aims/hypothesis: The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes. Methods: We performed a subanalysis among 4,220 individuals with diabetes in a large ongoing individual participant data meta-analysis involving 56,194 subjects from 17 population-based cohorts worldwide. We first refitted the risk factors of the Framingham heart risk score on the individuals without previous cardiovascular disease (baseline model) and then expanded this model with the mean common CIMT (CIMT model). The absolute 10 year risk for developing a myocardial infarction or stroke was estimated from both models. In individuals with diabetes we compared discrimination and calibration of the two models. Reclassification of individuals with diabetes was based on allocation to another cardiovascular risk category when mean common CIMT was added. Results: During a median follow-up of 8.7 years, 684 first-time cardiovascular events occurred among the population with diabetes. The C statistic was 0.67 for the Framingham model and 0.68 for the CIMT model. The absolute 10 year risk for developing a myocardial infarction or stroke was 16% in both models. There was no net reclassification improvement with the addition of mean common CIMT (1.7%; 95% CI -1.8, 3.8). There were no differences in the results between men and women. Conclusions/interpretation: There is no improvement in risk prediction in individuals with diabetes when measurement of the mean common CIMT is added to the Framingham risk score. Therefore, this measurement is not recommended for improving individual cardiovascular risk stratification in individuals with diabetes.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Carotid intima-media thickness

KW - Diabetes

KW - Prognosis

KW - Risk prediction

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