Combining endocrine and chemotherapy - Any true benefits?

Marc E Lippman, A. Buzdar, D. C. Tormey, W. L. McGuire

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

There is abundant evidence for a good response rate to combination chemotherapy in advanced breast cancer, and to endocrine therapy as well if the tumor is receptor-positive. The unresolved issue is whether patient outcomes, such as survival, are improved by combining these two separate approaches. Do the higher complete and partial response rates to combined chemo-endocrine therapy result in longer survival than when these therapies are used in sequence? Can appropriate endocrine manipulation sensitize tumor cells to subsequent treatment? Could there be some disadvantage to combining endocrine and chemotherapy? These questions are discussed here by a selected panel.

Original languageEnglish
Pages (from-to)251-259
Number of pages9
JournalBreast Cancer Research and Treatment
Volume4
Issue number4
StatePublished - Dec 1 1984
Externally publishedYes

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Drug Therapy
Survival
Therapeutics
Combination Drug Therapy
Neoplasms
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lippman, M. E., Buzdar, A., Tormey, D. C., & McGuire, W. L. (1984). Combining endocrine and chemotherapy - Any true benefits? Breast Cancer Research and Treatment, 4(4), 251-259.

Combining endocrine and chemotherapy - Any true benefits? / Lippman, Marc E; Buzdar, A.; Tormey, D. C.; McGuire, W. L.

In: Breast Cancer Research and Treatment, Vol. 4, No. 4, 01.12.1984, p. 251-259.

Research output: Contribution to journalArticle

Lippman, ME, Buzdar, A, Tormey, DC & McGuire, WL 1984, 'Combining endocrine and chemotherapy - Any true benefits?', Breast Cancer Research and Treatment, vol. 4, no. 4, pp. 251-259.
Lippman ME, Buzdar A, Tormey DC, McGuire WL. Combining endocrine and chemotherapy - Any true benefits? Breast Cancer Research and Treatment. 1984 Dec 1;4(4):251-259.
Lippman, Marc E ; Buzdar, A. ; Tormey, D. C. ; McGuire, W. L. / Combining endocrine and chemotherapy - Any true benefits?. In: Breast Cancer Research and Treatment. 1984 ; Vol. 4, No. 4. pp. 251-259.
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