Combining cellular and gene therapy approaches for treatment of intracranial tumors

Michelle J. Hickey, Noriyuki Kasahara, Barbara M. Mueller, Carol A. Kruse

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.

Original languageEnglish (US)
Article numbere25989
JournalOncoImmunology
Volume2
Issue number10
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Prodrugs
Genetic Therapy
Cytotoxic T-Lymphocytes
Heterografts
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Morbidity
Mortality
Brain
Enzymes
Therapeutics

Keywords

  • alloCTL
  • Brain cancer
  • Breast cancer
  • Gene therapy
  • Immunotherapy
  • Metastasis
  • Retrovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Combining cellular and gene therapy approaches for treatment of intracranial tumors. / Hickey, Michelle J.; Kasahara, Noriyuki; Mueller, Barbara M.; Kruse, Carol A.

In: OncoImmunology, Vol. 2, No. 10, e25989, 2013.

Research output: Contribution to journalArticle

Hickey, Michelle J. ; Kasahara, Noriyuki ; Mueller, Barbara M. ; Kruse, Carol A. / Combining cellular and gene therapy approaches for treatment of intracranial tumors. In: OncoImmunology. 2013 ; Vol. 2, No. 10.
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