Abstract
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
| Original language | English (US) |
|---|---|
| Article number | e25989 |
| Journal | OncoImmunology |
| Volume | 2 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2013 |
Keywords
- Brain cancer
- Breast cancer
- Gene therapy
- Immunotherapy
- Metastasis
- Retrovirus
- alloCTL
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology
Fingerprint Dive into the research topics of 'Combining cellular and gene therapy approaches for treatment of intracranial tumors'. Together they form a unique fingerprint.
Cite this
Hickey, M. J., Kasahara, N., Mueller, B. M., & Kruse, C. A. (2013). Combining cellular and gene therapy approaches for treatment of intracranial tumors. OncoImmunology, 2(10), [e25989]. https://doi.org/10.4161/onci.25989