Combining cellular and gene therapy approaches for treatment of intracranial tumors

Michelle J. Hickey; Noriyuki Kasahara; Barbara M. Mueller; Carol A. Kruse

doi:10.4161/onci.25989

Combining cellular and gene therapy approaches for treatment of intracranial tumors

Michelle J. Hickey, Noriyuki Kasahara, Barbara M. Mueller, Carol A. Kruse

Cell Biology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.

Original language	English (US)
Article number	e25989
Journal	OncoImmunology
Volume	2
Issue number	10
DOIs	https://doi.org/10.4161/onci.25989
State	Published - 2013

Keywords

Brain cancer
Breast cancer
Gene therapy
Immunotherapy
Metastasis
Retrovirus
alloCTL

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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title = "Combining cellular and gene therapy approaches for treatment of intracranial tumors",

abstract = "New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.",

keywords = "Brain cancer, Breast cancer, Gene therapy, Immunotherapy, Metastasis, Retrovirus, alloCTL",

author = "Hickey, {Michelle J.} and Noriyuki Kasahara and Mueller, {Barbara M.} and Kruse, {Carol A.}",

note = "Funding Information: Financial support for the study was supplied in part by USAMRMC 750 W81XWH-08–1-0734 (CAK), CBCRP 14IB-0114A (BMM), NIH RO1 CA121258 (NK), NIH/NCATS UCLA CTSI Grant Number UL1TR000124 (CAK/NK), the Joan S Holmes Memorial Research Fund (CAK), the Joan S Holmes Memorial Postdoctoral Fellowship (MJH).",

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AU - Kasahara, Noriyuki

AU - Mueller, Barbara M.

AU - Kruse, Carol A.

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PY - 2013

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KW - Breast cancer

KW - Gene therapy

KW - Immunotherapy

KW - Metastasis

KW - Retrovirus

KW - alloCTL

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