Combining cellular and gene therapy approaches for treatment of intracranial tumors

Michelle J. Hickey, Noriyuki Kasahara, Barbara M. Mueller, Carol A. Kruse

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.

Original languageEnglish (US)
Article numbere25989
JournalOncoImmunology
Volume2
Issue number10
DOIs
StatePublished - 2013

Keywords

  • Brain cancer
  • Breast cancer
  • Gene therapy
  • Immunotherapy
  • Metastasis
  • Retrovirus
  • alloCTL

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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