Abstract
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
| Original language | English (US) |
|---|---|
| Article number | e25989 |
| Journal | OncoImmunology |
| Volume | 2 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
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Keywords
- alloCTL
- Brain cancer
- Breast cancer
- Gene therapy
- Immunotherapy
- Metastasis
- Retrovirus
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology
Cite this
Combining cellular and gene therapy approaches for treatment of intracranial tumors. / Hickey, Michelle J.; Kasahara, Noriyuki; Mueller, Barbara M.; Kruse, Carol A.
In: OncoImmunology, Vol. 2, No. 10, e25989, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combining cellular and gene therapy approaches for treatment of intracranial tumors
AU - Hickey, Michelle J.
AU - Kasahara, Noriyuki
AU - Mueller, Barbara M.
AU - Kruse, Carol A.
PY - 2013
Y1 - 2013
N2 - New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
AB - New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
KW - alloCTL
KW - Brain cancer
KW - Breast cancer
KW - Gene therapy
KW - Immunotherapy
KW - Metastasis
KW - Retrovirus
UR - http://www.scopus.com/inward/record.url?scp=84890280183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890280183&partnerID=8YFLogxK
U2 - 10.4161/onci.25989
DO - 10.4161/onci.25989
M3 - Article
AN - SCOPUS:84890280183
VL - 2
JO - OncoImmunology
JF - OncoImmunology
SN - 2162-4011
IS - 10
M1 - e25989
ER -