Combining anatomical biomarkers with neuropsychological data for multidimensional classification of Alzheimer’s disease

Q. Zhou, M. Goryawala, M. Cabrerizo, J. Wang, W. Barker, R. Duara, M. Adjouadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

This study combines MRI data with neuropsychological Mini-Mental State Examination (MMSE) as a decisional space for Alzheimer’s disease (AD). A new sorting/ranking method selects variables that make up the dimensions of an optimal decisional space. Specifically, 189 structural MRI scans with 60 AD patients and 129 cognitively normal controls (CN) obtained at Mount Sinai Medical Center were used for empirical evaluation. The results suggest that by using only the two volumetric measures, Right-Hippocampus and left inferior lateral ventricle, along with MMSE scores yielded an average accuracy of 92.3% (sensitivity: 82.8%; specificity: 96.7%). The study is consistent with the widely accepted notion of hippocampal atrophy and ventricular enlargement seen in AD patients. Moreover, the study through its inherent sorting and statistical ranking of the different variables provides a complete mapping of the significant subcortical brain regions which may act as important biomarkers in predicting AD.

Original languageEnglish (US)
Title of host publicationProceedings of the 2013 International Conference on Image Processing, Computer Vision, and Pattern Recognition, IPCV 2013
EditorsHamid R. Arabnia, Leonidas Deligiannidis, Joan Lu, Fernando G. Tinetti, Jane You, George Jandieri, Gerald Schaefer, Ashu M. G. Solo, Vladimir Volkov
PublisherCSREA Press
Pages255-261
Number of pages7
ISBN (Electronic)1601322526, 9781601322524
StatePublished - 2013
Externally publishedYes
Event2013 International Conference on Image Processing, Computer Vision, and Pattern Recognition, IPCV 2013, at WORLDCOMP 2013 - Las Vegas, United States
Duration: Jul 22 2013Jul 25 2013

Publication series

NameProceedings of the 2013 International Conference on Image Processing, Computer Vision, and Pattern Recognition, IPCV 2013
Volume1

Conference

Conference2013 International Conference on Image Processing, Computer Vision, and Pattern Recognition, IPCV 2013, at WORLDCOMP 2013
Country/TerritoryUnited States
CityLas Vegas
Period7/22/137/25/13

Keywords

  • Alzheimer’s disease (AD)
  • Brain atrophy
  • Mini-Mental State Examination (MMSE)
  • Multi-dimensional classification
  • Neuropsychological test

ASJC Scopus subject areas

  • Computer Graphics and Computer-Aided Design
  • Computer Vision and Pattern Recognition

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