Combined use of the intravascular blood-pool agent, gadomer, and carbon dioxide: A novel type of double-contrast magnetic resonance angiography (MRA)

Robbert M. Maes, Jonathan S. Lewin, Jeffrey L. Duerk, Frank K. Wacker

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Purpose: To evaluate the combined use of carbon dioxide (CO2) and a gadolinium-based blood-pool agent for magnetic resonance angiography (MRA). Materials and Methods: After an initial intravenous injection of the blood-pool agent Gadomer (Schering AG, Germany), repeated transcatheter CO 2 injections were performed in the aorta and the renal arteries of two fully-anesthetized pigs. Real-time images were acquired using a true fast imaging with steady-state precession (FISP) sequence. Results: During the CO2 injections, the Gadomer-enhanced blood was totally replaced, resulting in an immediate, temporary, total signal loss in the vessel lumen. Susceptibility artifacts during the injections or catheter manipulations rarely occurred. Conclusion: Due to T1-shortening, the circulating blood-pool agent prevents flow artifacts during catheter manipulations because the steady-state is reached much earlier. Therefore, this double-contrast MRA method improves catheter conspicuity and might be helpful for guiding and controlling intravascular procedures during interventional MRI.

Original languageEnglish (US)
Pages (from-to)645-649
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume21
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Artifact reduction
  • Blood pool agent
  • Carbon dioxide
  • Interventional MRI
  • MRA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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