Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma: Local therapeutic effect and long-term survival rate

Riccardo Lencioni, A. Paolicchi, M. Moretti, F. Pinto, N. Armillotta, M. Di Giulio, A. Cicorelli, F. Donati, D. Cioni, C. Bartolozzi

Research output: Contribution to journalArticle

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Abstract

The aim of our study was to investigate local therapeutic effects and long-term results of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in the treatment of large hepatocellular carcinoma (HCC). Eight-six patients (67 males and 19 females, age range 48-75 years, mean age 65.1 years) with Child-Pugh class A (n = 48) or B (n = 38) liver cirrhosis and a large HCC (main tumor 3.1-8 cm in diameter with no more than two daughter nodules) were enrolled in a prospective study. All patients underwent a single TACE session followed by PEI. Follow-up ranged from 4 to 65 months (mean 27.8 months, median 26 months). No major complication occurred. The local therapeutic effect, as assessed on the basis of findings at CT and MR imaging, was complete response in 71 of 86 patients (82 %) and partial response in 15 of 86. Overall survival rates by the Kaplan-Meier method were 92 % at 1 year, 83 % at 2 years, 69 % at 3 years, 58 % at 4 years, and 47 % at 5 years. Survival of Child-Pugh A patients (75 % at 3 years and 59 % at 5 years) was significantly longer (p <0.01) than that of Child-Pugh B patients (61 % at 3 years and 35 % at 5 years). Combined TACE and PEI is an effective treatment for large HCC.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalEuropean Radiology
Volume8
Issue number3
StatePublished - 1998
Externally publishedYes

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Therapeutic Uses
Hepatocellular Carcinoma
Ethanol
Survival Rate
Injections
Therapeutics
Liver Cirrhosis
Prospective Studies
Survival
Neoplasms

Keywords

  • Alcohol
  • Liver neoplasms
  • Liver neoplasms, therapy
  • Liver, interventional procedure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma : Local therapeutic effect and long-term survival rate. / Lencioni, Riccardo; Paolicchi, A.; Moretti, M.; Pinto, F.; Armillotta, N.; Di Giulio, M.; Cicorelli, A.; Donati, F.; Cioni, D.; Bartolozzi, C.

In: European Radiology, Vol. 8, No. 3, 1998, p. 439-444.

Research output: Contribution to journalArticle

Lencioni, R, Paolicchi, A, Moretti, M, Pinto, F, Armillotta, N, Di Giulio, M, Cicorelli, A, Donati, F, Cioni, D & Bartolozzi, C 1998, 'Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma: Local therapeutic effect and long-term survival rate', European Radiology, vol. 8, no. 3, pp. 439-444.
Lencioni, Riccardo ; Paolicchi, A. ; Moretti, M. ; Pinto, F. ; Armillotta, N. ; Di Giulio, M. ; Cicorelli, A. ; Donati, F. ; Cioni, D. ; Bartolozzi, C. / Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma : Local therapeutic effect and long-term survival rate. In: European Radiology. 1998 ; Vol. 8, No. 3. pp. 439-444.
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abstract = "The aim of our study was to investigate local therapeutic effects and long-term results of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in the treatment of large hepatocellular carcinoma (HCC). Eight-six patients (67 males and 19 females, age range 48-75 years, mean age 65.1 years) with Child-Pugh class A (n = 48) or B (n = 38) liver cirrhosis and a large HCC (main tumor 3.1-8 cm in diameter with no more than two daughter nodules) were enrolled in a prospective study. All patients underwent a single TACE session followed by PEI. Follow-up ranged from 4 to 65 months (mean 27.8 months, median 26 months). No major complication occurred. The local therapeutic effect, as assessed on the basis of findings at CT and MR imaging, was complete response in 71 of 86 patients (82 {\%}) and partial response in 15 of 86. Overall survival rates by the Kaplan-Meier method were 92 {\%} at 1 year, 83 {\%} at 2 years, 69 {\%} at 3 years, 58 {\%} at 4 years, and 47 {\%} at 5 years. Survival of Child-Pugh A patients (75 {\%} at 3 years and 59 {\%} at 5 years) was significantly longer (p <0.01) than that of Child-Pugh B patients (61 {\%} at 3 years and 35 {\%} at 5 years). Combined TACE and PEI is an effective treatment for large HCC.",
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AU - Moretti, M.

AU - Pinto, F.

AU - Armillotta, N.

AU - Di Giulio, M.

AU - Cicorelli, A.

AU - Donati, F.

AU - Cioni, D.

AU - Bartolozzi, C.

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