Objective: To evaluate corneal graft survival and intraocular pressure control in eyes that have undergone combined penetrating keratoplasty and trabeculectomy with mitomycin C (MMC). Design: Retrospective noncomparative case series. Intervention: Penetrating keratoplasty combined with trabeculectomy with MMC and other surgical procedures. Participants: Twenty- four eyes of 22 patients undergoing combined penetrating keratoplasty and trabeculectomy with mitomycin C. Main Outcome Measures: Corneal graft clarity and intraocular pressure control. Results: The cumulative probability of corneal graft survival was 85% at 1 year and 60% at 2 years. The cumulative probability of adequate pressure control was 67% at 3 months, 55% at 12 months, and 50% at 24 months. The incidence of bleb failure was higher in cases involving additional concomitant procedures, such as anterior vitrectomy, lens implantation or exchange, and drainage tube implantation. Conclusions: Combined penetrating keratoplasty and trabeculectomy with mitomycin C is associated with good corneal graft survival but also a risk of early failure of intraocular pressure control. Other concomitant procedures during the combined penetrating keratoplasty/trabeculectomy may increase the risk of early bleb failure.
ASJC Scopus subject areas