Combined off-pump coronary bypass grafting without heparin and liver transplantation: A novel approach to a complex dilemma

Nicolas A. Brozzi, Thiago Beduschi, Tomas Salerno, Renzo Cifuentes, Ali Ghodsizad, Eric Martin, Rodrigo Vianna, Matthias Loebe

Research output: Contribution to journalArticle

Abstract

Cardiac disease is a leading cause of early mortality for patients undergoing liver transplantation (LT), and severe coronary artery disease (CAD) is usually considered a contraindication for LT in patients with cirrhosis. Incidence of CAD in LT candidates has increased in recent years. While stable patients might be candidates for percutaneous interventions, patients with decompensated liver failure, or critical coronary lesions present a therapeutic challenge, and are often not considered candidates for LT. We present the case of a 60 year old male patient with decompensated liver failure, and critical CAD, who received successful combined off-pump coronary bypass grafting without heparin and LT using ex vivo normothermic liver perfusion machine. This approach represents a novel strategy to offer LT to this very selective group of patients.

Original languageEnglish (US)
JournalJournal of cardiac surgery
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Liver Transplantation
Heparin
Coronary Artery Disease
Liver Failure
Heart Diseases
Fibrosis
Perfusion
Mortality
Liver
Incidence

Keywords

  • coronary artery disease
  • liver transplant
  • OPCABG

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Combined off-pump coronary bypass grafting without heparin and liver transplantation : A novel approach to a complex dilemma. / Brozzi, Nicolas A.; Beduschi, Thiago; Salerno, Tomas; Cifuentes, Renzo; Ghodsizad, Ali; Martin, Eric; Vianna, Rodrigo; Loebe, Matthias.

In: Journal of cardiac surgery, 01.01.2019.

Research output: Contribution to journalArticle

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