Combined intratumor cisplatinum injection and Nd: YAG laser therapy

Ines P. Graeber, Adrien Eshraghi, Marcos B. Paiva, Woo H. Paek, Dan J. Castro, Sergije Jovanovic, Hans Scherer, Jacques Soudant, Romaine E. Saxton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives/Hypothesis: Interstitial laser therapy (ILT) has become useful for tumor palliation in patients with advanced head and neck cancer. Cisplatinure chemotherapy also is a frequent adjuvant treatment for recurrent tumors, but systemic toxicity limits application. Intratumor cisplatinum injection combined with ILT may improve therapy of these recurrent tumors with reduced toxicity. Study Design: Prospective. Tumor transplants were injected with cisplatinum in a gel implant before ILT to evaluate treatment response and toxicity in a preclinical study. Methods: UCLA-P3 human squamous cell carcinoma tumors were grown as subcutaneous transplants in nude mice and treated by intratumor injection of 2 mg/mL cisplatinum in a slow-release, collagen-based gel carrier 4 hours before interstitial implantation of Nd:YAG laser fiberoptics to induce local tumor hyperthermia. Treatment efficacy and toxicity were followed for 12 weeks after combined drug and laser therapy compared with ILT alone. Results: Combined cisplatinum gel and ILT was a significant improvement (P < .01 by chi-square test) and induced 57% complete responses without regrowth in 21 transplanted tumors compared with only 24% in 21 tumors after ILT alone during 12-week follow-up. Recurrences in both cases appeared to result from nonuniform laser energy delivery within tumors via the implanted fiberoptic tip. Conclusions: The results of this experimental combined cisplatinum and ILT study suggest it may be possible to improve treatment of advanced head and neck cancer by intratumor injection of gel implants containing the drug followed by interstitial Nd:YAG laser hyperthermia.

Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalLaryngoscope
Volume109
Issue number3
StatePublished - Mar 23 1999
Externally publishedYes

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Solid-State Lasers
Laser Therapy
Injections
Neoplasms
Gels
Head and Neck Neoplasms
Drug Implants
Transplants
Drug Therapy
Induced Hyperthermia
Chi-Square Distribution
Therapeutics
Nude Mice
Squamous Cell Carcinoma
Lasers
Fever
Collagen
Prospective Studies
Recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Graeber, I. P., Eshraghi, A., Paiva, M. B., Paek, W. H., Castro, D. J., Jovanovic, S., ... Saxton, R. E. (1999). Combined intratumor cisplatinum injection and Nd: YAG laser therapy. Laryngoscope, 109(3), 447-454.

Combined intratumor cisplatinum injection and Nd : YAG laser therapy. / Graeber, Ines P.; Eshraghi, Adrien; Paiva, Marcos B.; Paek, Woo H.; Castro, Dan J.; Jovanovic, Sergije; Scherer, Hans; Soudant, Jacques; Saxton, Romaine E.

In: Laryngoscope, Vol. 109, No. 3, 23.03.1999, p. 447-454.

Research output: Contribution to journalArticle

Graeber, IP, Eshraghi, A, Paiva, MB, Paek, WH, Castro, DJ, Jovanovic, S, Scherer, H, Soudant, J & Saxton, RE 1999, 'Combined intratumor cisplatinum injection and Nd: YAG laser therapy', Laryngoscope, vol. 109, no. 3, pp. 447-454.
Graeber IP, Eshraghi A, Paiva MB, Paek WH, Castro DJ, Jovanovic S et al. Combined intratumor cisplatinum injection and Nd: YAG laser therapy. Laryngoscope. 1999 Mar 23;109(3):447-454.
Graeber, Ines P. ; Eshraghi, Adrien ; Paiva, Marcos B. ; Paek, Woo H. ; Castro, Dan J. ; Jovanovic, Sergije ; Scherer, Hans ; Soudant, Jacques ; Saxton, Romaine E. / Combined intratumor cisplatinum injection and Nd : YAG laser therapy. In: Laryngoscope. 1999 ; Vol. 109, No. 3. pp. 447-454.
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abstract = "Objectives/Hypothesis: Interstitial laser therapy (ILT) has become useful for tumor palliation in patients with advanced head and neck cancer. Cisplatinure chemotherapy also is a frequent adjuvant treatment for recurrent tumors, but systemic toxicity limits application. Intratumor cisplatinum injection combined with ILT may improve therapy of these recurrent tumors with reduced toxicity. Study Design: Prospective. Tumor transplants were injected with cisplatinum in a gel implant before ILT to evaluate treatment response and toxicity in a preclinical study. Methods: UCLA-P3 human squamous cell carcinoma tumors were grown as subcutaneous transplants in nude mice and treated by intratumor injection of 2 mg/mL cisplatinum in a slow-release, collagen-based gel carrier 4 hours before interstitial implantation of Nd:YAG laser fiberoptics to induce local tumor hyperthermia. Treatment efficacy and toxicity were followed for 12 weeks after combined drug and laser therapy compared with ILT alone. Results: Combined cisplatinum gel and ILT was a significant improvement (P < .01 by chi-square test) and induced 57{\%} complete responses without regrowth in 21 transplanted tumors compared with only 24{\%} in 21 tumors after ILT alone during 12-week follow-up. Recurrences in both cases appeared to result from nonuniform laser energy delivery within tumors via the implanted fiberoptic tip. Conclusions: The results of this experimental combined cisplatinum and ILT study suggest it may be possible to improve treatment of advanced head and neck cancer by intratumor injection of gel implants containing the drug followed by interstitial Nd:YAG laser hyperthermia.",
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