Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data

Yara Younan, Anthony Martinez, Nickolas Reimer, Mark Edgar, Felix Gonzalez, Monica Umpierrez, Ty Subhawong, Adam D. Singer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives: Compile the largest study to date on the imaging and clinical features of the classic spindle cell/pleomorphic lipoma spectrum and suggest this diagnosis be included in the differential for benign and malignant macroscopic fat-containing soft tissue masses regardless of the mass location or patient demographics. Materials and methods: An institutional search was performed to identify all available classic-type spindle cell/pleomorphic lipomas with available demographic and imaging data. Images and reports were analyzed by one MSK-trained radiologist and radiographic, anatomic and clinical data were recorded. Additionally, a literature search was performed to identify studies describing the spindle cell lipoma spectrum imaging features and were combined with institutional data. Results: Forty-two institutional cases were identified, 37 of which had MRIs performed among which 21 had images available (T1- and T2-weighted pulse sequences) for review while the remainder had outside reports detailing the mass imaging features. There was a mean age of 57 with 79% of cases occurring in males. Contrary to prior reports, 57% of masses were subcutaneous, and the neck and back region accounted for 26% of cases. When the institutional cases were combined with available data in the literature, there was a new sample size of 91 masses, 74 of which had MRI and/or CT data. Eighty-seven percent of masses were heterogeneous, 51% were composed of less than 75% fat, 65% were in the back, neck or shoulder region, 27% of masses were deep and 91% demonstrated enhancement. Eighty-two percent of patients were males with a mean age of 58 at excision. Conclusion: Imaging features, patient demographics and tumor location alone are not enough to differentiate tumors of the spindle cell lipoma spectrum from other macroscopic fat-containing benign and malignant tumors, and these entities should be included in the same imaging differential diagnosis.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalSkeletal Radiology
StateAccepted/In press - Aug 19 2017


  • Lipoma
  • MRI
  • Pleomorphic
  • Sarcoma
  • Spindle cell

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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