Combination therapy with renin-angiotensin system blockers

Will amlodipine replace hydrochlorothiazide?

Thor Tejada, Alessia Fornoni, Oliver Lenz, Barry J Materson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Amlodipine is a highly effective and safe antihypertensive dihydropyridine calcium channel blocker. It is even more effective when used in combination with other antihypertensive medications, including hydrochlorothiazide. When antihypertensive calcium channel blockers were first introduced, evidence in the laboratory that they had some natriuretic properties was adduced to suggest that they would be "the diuretics of the 1990s." This turned out not to be the case. Because of its clinical efficacy, amlodipine is frequently used in fixed-dose combination products, but it is not likely to replace hydrochlorothiazide.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalCurrent Hypertension Reports
Volume9
Issue number4
DOIs
StatePublished - Aug 1 2007

Fingerprint

Amlodipine
Hydrochlorothiazide
Renin-Angiotensin System
Antihypertensive Agents
Calcium Channel Blockers
Diuretics
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Combination therapy with renin-angiotensin system blockers : Will amlodipine replace hydrochlorothiazide? / Tejada, Thor; Fornoni, Alessia; Lenz, Oliver; Materson, Barry J.

In: Current Hypertension Reports, Vol. 9, No. 4, 01.08.2007, p. 284-290.

Research output: Contribution to journalArticle

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