Combination therapy in the treatment of hypertension

Barry J. Materson, Richard A. Preston

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Evidence supports the concept that therapeutic reduction of intra-arterial pressure (blood pressure) well into the biologically normal range confers substantial protection against death and target organ damage associated with arterial hypertension. This is especially true for patients who also have diabetes mellitus, chronic renal disease, isolated systolic hypertension, or other cardiovascular risk factors. There is also evidence that most patients will require more than one drug in order to achieve these more aggressive therapeutic goals. Therefore, it has become appropriate to use more than one drug as initial therapy for such patients (1). Many commercially available combination products are now recommended for initial antihypertensive therapy.

Original languageEnglish (US)
Title of host publicationHypertension
Subtitle of host publicationPrinciples and Practice
PublisherCRC Press
Number of pages14
ISBN (Electronic)9780849356001
ISBN (Print)0824728556, 9780824728557
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)


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