Combination chemotherapy and radiotherapy for small-cell carcinoma of the esophagus: A case report of long-term survival and review of the literature

A. M. Hussein, L. G. Feun, K. S. Sridhar, P. Benedetto, S. Waldman, C. L. Otrakji

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Small-cell carcinoma of the esophagus is a rare tumor and has received little attention until recent years. It should be differentiated from the far more common poorly differentiated squamous-cell carcinoma of the esophagus, because treatment by surgical resection alone or by radiation therapy results in limited survival of a few months. It is now recognized that esophageal small-cell carcinoma presents with early widespread dissemination and is chemosensitive, similar to primary small-cell carcinoma of the lung. We report on a patient with small-cell carcinoma of the esophagus treated with combination chemotherapy consisting of cyclophosphamide, vincristine, and VP-16 followed by local radiation therapy. Pathologic complete remission was achieved. The patient is currently in remission 22 months after diagnosis, the longest survival reported thus far.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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