Coma and axonal degeneration in vitamin B 12 deficiency

K. S. Kosik, T. F. Mullins, Walter G Bradley, L. D. Tempelis, A. J. Cretella

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A 23-year-old woman with pernicious anemia, previously treated with folic acid, demonstrated an unusually rapid and severe course of neurologic deterioration. She was first seen with coma, myelopathy, and peripheral neuropathy. Her EEG showed repetitive nonperiodic suppression bursts, probably related to the severe impairment of consciousness. A sural nerve biopsy specimen revealed prominent axonal degeneration. With cyanocobalamin treatment, she regained normal mentation and the use of the upper limbs. She remains paraplegic, however, with a T10 sensory level.

Original languageEnglish
Pages (from-to)590-592
Number of pages3
JournalArchives of Neurology
Volume37
Issue number9
StatePublished - Nov 18 1980
Externally publishedYes

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Vitamin B 12 Deficiency
Pernicious Anemia
Sural Nerve
Spinal Cord Diseases
Peripheral Nervous System Diseases
Vitamin B 12
Coma
Consciousness
Folic Acid
Upper Extremity
Nervous System
Electroencephalography
Biopsy
Therapeutics
Nerve
Electroencephalogram
Vitamins
Degeneration
Suppression
Impairment

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kosik, K. S., Mullins, T. F., Bradley, W. G., Tempelis, L. D., & Cretella, A. J. (1980). Coma and axonal degeneration in vitamin B 12 deficiency. Archives of Neurology, 37(9), 590-592.

Coma and axonal degeneration in vitamin B 12 deficiency. / Kosik, K. S.; Mullins, T. F.; Bradley, Walter G; Tempelis, L. D.; Cretella, A. J.

In: Archives of Neurology, Vol. 37, No. 9, 18.11.1980, p. 590-592.

Research output: Contribution to journalArticle

Kosik, KS, Mullins, TF, Bradley, WG, Tempelis, LD & Cretella, AJ 1980, 'Coma and axonal degeneration in vitamin B 12 deficiency', Archives of Neurology, vol. 37, no. 9, pp. 590-592.
Kosik KS, Mullins TF, Bradley WG, Tempelis LD, Cretella AJ. Coma and axonal degeneration in vitamin B 12 deficiency. Archives of Neurology. 1980 Nov 18;37(9):590-592.
Kosik, K. S. ; Mullins, T. F. ; Bradley, Walter G ; Tempelis, L. D. ; Cretella, A. J. / Coma and axonal degeneration in vitamin B 12 deficiency. In: Archives of Neurology. 1980 ; Vol. 37, No. 9. pp. 590-592.
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