Colorimetric detection of cyanide with a chromogenic oxazine

Massimiliano Tomasulo, Françisco M. Raymo

Research output: Contribution to journalArticlepeer-review

234 Scopus citations


(Chemical Equation Presented) We have designed a chromogenic oxazine for the colorimetric detection of cyanide. Indeed, the [1,3]oxazine ring of our compound opens to form a 4-nitrophenylazophenolate chromophore in response to cyanide. This quantitative chromogenic transformation permits the detection of micromolar concentrations of cyanide in water. Furthermore, our chromogenic oxazine is insensitive to the presence of large concentrations of fluoride, chloride, bromide, or iodide anions, which are generally the principal interferents in the colorimetric detection of cyanide.

Original languageEnglish (US)
Pages (from-to)4633-4636
Number of pages4
JournalOrganic letters
Issue number21
StatePublished - Oct 13 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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