Colorectal liver metastases: Regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: An update

Thomas J. Vogl, Stephan Zangos, Katrin Eichler, Danny Yakoub, Mohamed Nabil

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Liver metastasis is one of the main problems encountered in colorectal cancer management as the liver is the most common metastatic site. Several treatment options are available, among which transarterial chemotherapy has proved effective in achieving some local tumour control, improving the quality of life through symptomatic control as well as survival time. The present paper is intended to provide an overview of the techniques, indications and results of regional chemotherapy, which comprises transarterial chemoembolization (TACE) and chemoperfusion. This treatment approach has symptomatic, palliative, adjuvant and potentially curative objectives. We reviewed the studies involving TACE and chemoperfusion of colorectal liver metastases during the last few years to update the previous reviews published on this subject. The results achieved were so variable, due to the variations in patient selection criteria and regimens used between the different studies. The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments.

Original languageEnglish (US)
Pages (from-to)1025-1034
Number of pages10
JournalEuropean Radiology
Volume17
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Neoplasm Metastasis
Drug Therapy
Patient Selection
Liver
Colorectal Neoplasms
Quality of Life
Therapeutics
Neoplasms

Keywords

  • Chemoembolization
  • HAI
  • Hepatic arterial infusion
  • Liver metastases
  • Regional chemotherapy
  • TACE

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Colorectal liver metastases : Regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: An update. / Vogl, Thomas J.; Zangos, Stephan; Eichler, Katrin; Yakoub, Danny; Nabil, Mohamed.

In: European Radiology, Vol. 17, No. 4, 04.2007, p. 1025-1034.

Research output: Contribution to journalArticle

Vogl, Thomas J. ; Zangos, Stephan ; Eichler, Katrin ; Yakoub, Danny ; Nabil, Mohamed. / Colorectal liver metastases : Regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: An update. In: European Radiology. 2007 ; Vol. 17, No. 4. pp. 1025-1034.
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