Abstract
Liver metastasis is one of the main problems encountered in colorectal cancer management as the liver is the most common metastatic site. Several treatment options are available, among which transarterial chemotherapy has proved effective in achieving some local tumour control, improving the quality of life through symptomatic control as well as survival time. The present paper is intended to provide an overview of the techniques, indications and results of regional chemotherapy, which comprises transarterial chemoembolization (TACE) and chemoperfusion. This treatment approach has symptomatic, palliative, adjuvant and potentially curative objectives. We reviewed the studies involving TACE and chemoperfusion of colorectal liver metastases during the last few years to update the previous reviews published on this subject. The results achieved were so variable, due to the variations in patient selection criteria and regimens used between the different studies. The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1025-1034 |
| Number of pages | 10 |
| Journal | European Radiology |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2007 |
| Externally published | Yes |
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Keywords
- Chemoembolization
- HAI
- Hepatic arterial infusion
- Liver metastases
- Regional chemotherapy
- TACE
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Colorectal liver metastases : Regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: An update. / Vogl, Thomas J.; Zangos, Stephan; Eichler, Katrin; Yakoub, Danny; Nabil, Mohamed.
In: European Radiology, Vol. 17, No. 4, 04.2007, p. 1025-1034.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Colorectal liver metastases
T2 - Regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: An update
AU - Vogl, Thomas J.
AU - Zangos, Stephan
AU - Eichler, Katrin
AU - Yakoub, Danny
AU - Nabil, Mohamed
PY - 2007/4
Y1 - 2007/4
N2 - Liver metastasis is one of the main problems encountered in colorectal cancer management as the liver is the most common metastatic site. Several treatment options are available, among which transarterial chemotherapy has proved effective in achieving some local tumour control, improving the quality of life through symptomatic control as well as survival time. The present paper is intended to provide an overview of the techniques, indications and results of regional chemotherapy, which comprises transarterial chemoembolization (TACE) and chemoperfusion. This treatment approach has symptomatic, palliative, adjuvant and potentially curative objectives. We reviewed the studies involving TACE and chemoperfusion of colorectal liver metastases during the last few years to update the previous reviews published on this subject. The results achieved were so variable, due to the variations in patient selection criteria and regimens used between the different studies. The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments.
AB - Liver metastasis is one of the main problems encountered in colorectal cancer management as the liver is the most common metastatic site. Several treatment options are available, among which transarterial chemotherapy has proved effective in achieving some local tumour control, improving the quality of life through symptomatic control as well as survival time. The present paper is intended to provide an overview of the techniques, indications and results of regional chemotherapy, which comprises transarterial chemoembolization (TACE) and chemoperfusion. This treatment approach has symptomatic, palliative, adjuvant and potentially curative objectives. We reviewed the studies involving TACE and chemoperfusion of colorectal liver metastases during the last few years to update the previous reviews published on this subject. The results achieved were so variable, due to the variations in patient selection criteria and regimens used between the different studies. The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments.
KW - Chemoembolization
KW - HAI
KW - Hepatic arterial infusion
KW - Liver metastases
KW - Regional chemotherapy
KW - TACE
UR - http://www.scopus.com/inward/record.url?scp=34248650698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248650698&partnerID=8YFLogxK
U2 - 10.1007/s00330-006-0372-5
DO - 10.1007/s00330-006-0372-5
M3 - Article
C2 - 16944163
AN - SCOPUS:34248650698
VL - 17
SP - 1025
EP - 1034
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 4
ER -