Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments

D. M. Goldenberg; T. J. Wlodkowski; R. M. Sharkey; E. B. Silberstein; A. N. Serafini; I. I. Garty; R. L. Van Heertum; E. A. Higginbotham-Ford; J. A. Kotler; N. Balasubramanian; L. C. Swayne; H. J. Hansen; C. M. Pinsky

Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments

D. M. Goldenberg, T. J. Wlodkowski, R. M. Sharkey, E. B. Silberstein, A. N. Serafini, I. I. Garty, R. L. Van Heertum, E. A. Higginbotham-Ford, J. A. Kotler, N. Balasubramanian, L. C. Swayne, H. J. Hansen, C. M. Pinsky

Radiology

Research output: Contribution to journal › Article

51 Scopus citations

Abstract

This prospective, randomized multicenter study in 62 patients was designed to evaluate the efficacy and safety of radioimmunodetection (RAID) with ¹²³I-labeled fragments, F(ab')₂ and Fab', of IMMU-4, an anti-CEA monoclonal antibody (Immu-RAID-CEA). It was found that ImmuRAID-CEA was safe and disclosed colorectal cancer sites at least 1 cm in size. The positive predictive value by lesions was 77% initially, and increased to 91% after 7 mo of follow-up. Only one patient developed a low level of HAMA. In 17 patients with 32 surgically confirmed lesions, there were 9% true-positive lesions for CT when RAID was false-negative, and 22% for RAID when CT was false-negative. Either CT or RAID detected all 32 lesions. In this small series, therefore, RAID was shown to complement CT findings by confirming suspected tumors and disclosing new lesions which had previously been occult.

Original language	English (US)
Pages (from-to)	61-70
Number of pages	10
Journal	Journal of Nuclear Medicine
Volume	34
Issue number	1
State	Published - 1993

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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Goldenberg, D. M., Wlodkowski, T. J., Sharkey, R. M., Silberstein, E. B., Serafini, A. N., Garty, I. I., Van Heertum, R. L., Higginbotham-Ford, E. A., Kotler, J. A., Balasubramanian, N., Swayne, L. C., Hansen, H. J., & Pinsky, C. M. (1993). Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments. Journal of Nuclear Medicine, 34(1), 61-70.

Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments. / Goldenberg, D. M.; Wlodkowski, T. J.; Sharkey, R. M.; Silberstein, E. B.; Serafini, A. N.; Garty, I. I.; Van Heertum, R. L.; Higginbotham-Ford, E. A.; Kotler, J. A.; Balasubramanian, N.; Swayne, L. C.; Hansen, H. J.; Pinsky, C. M.

In: Journal of Nuclear Medicine, Vol. 34, No. 1, 1993, p. 61-70.

Research output: Contribution to journal › Article

Goldenberg, D. M. ; Wlodkowski, T. J. ; Sharkey, R. M. ; Silberstein, E. B. ; Serafini, A. N. ; Garty, I. I. ; Van Heertum, R. L. ; Higginbotham-Ford, E. A. ; Kotler, J. A. ; Balasubramanian, N. ; Swayne, L. C. ; Hansen, H. J. ; Pinsky, C. M. / Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments. In: Journal of Nuclear Medicine. 1993 ; Vol. 34, No. 1. pp. 61-70.

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abstract = "This prospective, randomized multicenter study in 62 patients was designed to evaluate the efficacy and safety of radioimmunodetection (RAID) with 123I-labeled fragments, F(ab')2 and Fab', of IMMU-4, an anti-CEA monoclonal antibody (Immu-RAID-CEA). It was found that ImmuRAID-CEA was safe and disclosed colorectal cancer sites at least 1 cm in size. The positive predictive value by lesions was 77% initially, and increased to 91% after 7 mo of follow-up. Only one patient developed a low level of HAMA. In 17 patients with 32 surgically confirmed lesions, there were 9% true-positive lesions for CT when RAID was false-negative, and 22% for RAID when CT was false-negative. Either CT or RAID detected all 32 lesions. In this small series, therefore, RAID was shown to complement CT findings by confirming suspected tumors and disclosing new lesions which had previously been occult.",

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AU - Serafini, A. N.

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AU - Van Heertum, R. L.

AU - Higginbotham-Ford, E. A.

AU - Kotler, J. A.

AU - Balasubramanian, N.

AU - Swayne, L. C.

AU - Hansen, H. J.

AU - Pinsky, C. M.

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