Color Doppler demonstration of segmental portal flow reversal: An early sign of hepatic veno-occlusive disease in an infant

Eduard Ghersin, Olga R. Brook, Diana Gaitini, Ahuva Engel

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Hepatic veno-occlusive disease (HVOD) is a relatively frequent complication of bone marrow transplantation (BMT), with a reported prevalence of 1% to 54%. The role of color duplex ultrasonography (CDU) in the diagnosis and monitoring of HVOD is controversial; some authors advocate its use, whereas others find it insensitive and nonspecific. Hepatofugal flow in the main portal vein is regarded as a relatively specific finding of severe HVOD; however, it is of limited value because it seldom occurs. Here we report HVOD in an infant who previously underwent BMT. The HVOD was diagnosed early by demonstration of hepatofugal flow in only 1 segmental portal vein. After treatment with high-dose methylprednisolone and defibrotide, CDU showed reversal to hepatopetal flow accompanied by marked clinical improvement.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalJournal of Ultrasound in Medicine
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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