Collateral sensitivity to radiation and CIS-platinum in a multidrug-resistant human leukemia cell line

Jonathan Cho, Young Lee, Jose Lutzky, Leslie Redpath, Lewis Slater

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Although collateral sensitivity to gamma radiation has previously been described in multidrug-resistant tumor cell lines, we describe here a multidrug-resistant human T-cell acute lymphatic leukemia cell line, L100, which displayed increased sensitivity to both gamma radiation and cis-platinum. Cis-platinum cytotoxicity of parental L0 cells and L100 cells was enhanced, whereas radiation sensitivity of L0 and L100 cells was unaltered by glutathione depletion. These results indicate that disparate mechanisms are operative in the collateral sensitivity of L100 cells to gamma radiation and cis-platinum.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalCancer Chemotherapy And Pharmacology
Volume37
Issue number1-2
DOIs
StatePublished - Jan 1995
Externally publishedYes

Keywords

  • Cis-platinum
  • Leukemia
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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