Collagenous colitis

H. Rams, A. I. Rogers, L. Ghandur-Mnaymneh

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Two hypotheses have been proposed to explain the pathogenesis and cause of the increased subepithelial collagen deposition that occurs in patients with collagenous colitis, a rare disease of unknown cause. One hypothesis considers an inflammatory origin, and the other, a local abnormality of collagen synthesis. An analysis of clinical, endoscopic and histologic findings from one of our patients and from previously published cases suggests that collagenous colitis is a form of inflammatory bowel disease characterized by localization of the initial injury to the superficial subepithelial zone and with subsequent fibrosis in that area. The data show a spectrum of clinical and histologic changes that represent different stages in the evolution of the inflammatory process.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalAnnals of internal medicine
Volume106
Issue number1
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Internal Medicine

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