Collagenous colitis

H. Rams, A. I. Rogers, L. Ghandur-Mnaymneh

Research output: Contribution to journalReview article

80 Scopus citations


Two hypotheses have been proposed to explain the pathogenesis and cause of the increased subepithelial collagen deposition that occurs in patients with collagenous colitis, a rare disease of unknown cause. One hypothesis considers an inflammatory origin, and the other, a local abnormality of collagen synthesis. An analysis of clinical, endoscopic and histologic findings from one of our patients and from previously published cases suggests that collagenous colitis is a form of inflammatory bowel disease characterized by localization of the initial injury to the superficial subepithelial zone and with subsequent fibrosis in that area. The data show a spectrum of clinical and histologic changes that represent different stages in the evolution of the inflammatory process.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalAnnals of internal medicine
Issue number1
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Internal Medicine

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    Rams, H., Rogers, A. I., & Ghandur-Mnaymneh, L. (1987). Collagenous colitis. Annals of internal medicine, 106(1), 108-113.