Collagen vicryl - A new dural prosthesis

N. Meddings, R. Scott, Ross Bullock, D. A. French, T. A. Hide, S. D. Gorham

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

No ideal dural grafting material is currently available. Many materials have been evaluated in this role, and for many neurosurgeons cadaveric human lyophilized dura has been popular. Recently this material has been putatively associated with Creutzfeldt-Jakob disease. In this study we compared three degradable materials, collagen vicryl (Bovine collagen coated vicryl mesh), Zenoderm (Porcine dermis) and Lyodura (Lyophilized human cadaveric dura) as dural substitutes. In an experimental model using the New Zealand White Rabbit the materials were implanted into dural defects of dimensions 1.7 cm by 1 cm. In the control group the dura was not repaired. In total 47 animals were used and sacrificed at time intervals of 2, 4, 8, 12, and 24 weeks. On gross examination the collagen vicryl produced few adhesions to the cerebral cortex and was replaced by a neomembrane which showed good union with the host dura. In the control group no new layer was formed and there were severe cortical adhesions. Zenoderm and Lyodura remained undegraded and produced more adherence to the cerebral cortex than the collagen vicryl implant. The histological examination showed collagen vicryl to support ingrowth of fibroblasts and the production of a new collagen layer which by 3 months resembled the original host dura. The inflammatory response to the implant did not persist after 3 months. The other substitutes were revitalized by host cells but remained undegraded at 6 months with ingrowth of woven bone and persistence of inflammatory and foreign body response. The results show collagen vicryl to be a suitable dural substitute with potential advantages over other currently used degradable materials, and should be evaluated more fully, both in laboratory studies and clinically.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalActa Neurochirurgica
Volume117
Issue number1-2
DOIs
StatePublished - Mar 1 1992
Externally publishedYes

Fingerprint

Polyglactin 910
collagens
Collagen
Prostheses and Implants
cerebral cortex
substitutes
Cerebral Cortex
adhesion
Adhesion
examination
foreign bodies
Control Groups
unions
Creutzfeldt-Jakob Syndrome
rabbits
New Zealand
fibroblasts
Fibroblasts
Dermis
Foreign Bodies

Keywords

  • collagen vicryl
  • Dural prosthesis
  • lyodura
  • zenoderm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Meddings, N., Scott, R., Bullock, R., French, D. A., Hide, T. A., & Gorham, S. D. (1992). Collagen vicryl - A new dural prosthesis. Acta Neurochirurgica, 117(1-2), 53-58. https://doi.org/10.1007/BF01400636

Collagen vicryl - A new dural prosthesis. / Meddings, N.; Scott, R.; Bullock, Ross; French, D. A.; Hide, T. A.; Gorham, S. D.

In: Acta Neurochirurgica, Vol. 117, No. 1-2, 01.03.1992, p. 53-58.

Research output: Contribution to journalArticle

Meddings, N, Scott, R, Bullock, R, French, DA, Hide, TA & Gorham, SD 1992, 'Collagen vicryl - A new dural prosthesis', Acta Neurochirurgica, vol. 117, no. 1-2, pp. 53-58. https://doi.org/10.1007/BF01400636
Meddings N, Scott R, Bullock R, French DA, Hide TA, Gorham SD. Collagen vicryl - A new dural prosthesis. Acta Neurochirurgica. 1992 Mar 1;117(1-2):53-58. https://doi.org/10.1007/BF01400636
Meddings, N. ; Scott, R. ; Bullock, Ross ; French, D. A. ; Hide, T. A. ; Gorham, S. D. / Collagen vicryl - A new dural prosthesis. In: Acta Neurochirurgica. 1992 ; Vol. 117, No. 1-2. pp. 53-58.
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