Collagen type ii in the otic extracellular matrix effect on inner ear development

Thomas R Van De Water, Vera Galinovic-Schwartz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Immunocytochemistry was used to demonstrate type II collagen distribution during normal development of the mouse inner ear and in two malformed inner ears. Patterns of inner ear abnormalities and type II collagen distribution were compared between the malformed labyrinth of a mouse mutation (disproportionate micromelia, Dmm) and otic expiants exposed to the teratogenic action of an L-proline analog, L-azetidine-2-carboxylic acid (LACA). The results suggest that type II collagen is an important constituent of the developing inner ear's extracellular matrix. Disruptions of the spatial and temporal pattern of collagen type II can adversely affect morphogenesis of the inner ear. A common mechanism of action is postulated for the causation of both the genetic and teratogen-induced inner ear malformations (i.e. disruption of the secretion of collagens to the otic extracellular matrix).

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalHearing Research
Volume30
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Inner Ear
Extracellular Matrix
Ear
Collagen
Collagen Type II
Azetidinecarboxylic Acid
Teratogens
Normal Distribution
Morphogenesis
Proline
Causality
Immunohistochemistry
Mutation

Keywords

  • Collagen type II
  • Epithelial-mesenchymal tissue interaction
  • Extracellular matrix
  • Inner ear
  • Malformation

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Collagen type ii in the otic extracellular matrix effect on inner ear development. / Van De Water, Thomas R; Galinovic-Schwartz, Vera.

In: Hearing Research, Vol. 30, No. 1, 01.01.1987, p. 39-47.

Research output: Contribution to journalArticle

Van De Water, Thomas R ; Galinovic-Schwartz, Vera. / Collagen type ii in the otic extracellular matrix effect on inner ear development. In: Hearing Research. 1987 ; Vol. 30, No. 1. pp. 39-47.
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