Collagen-rich tumors of soft tissues: An overview

G. Petur Nielsen, John X. O'Connell, Bret M. Wehrli, Andrew E. Rosenberg

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Although relatively common, soft tissue tumors frequently present diagnostic problems for practicing pathologists. Immunohistochemistry has facilitated the diagnosis of many mesenchymal tumors; however, there is considerable overlap in the staining profiles among cells demonstrating fibroblastic and myofibroblastic differentiation. It has been our experience that soft tissue tumors associated with abundant extracellular collagen deposition commonly cause problems in classification. One reason for this is that tumors displaying this morphology include representatives from different histogenetic families. Specifically, tumors exhibiting fibroblastic, myofibroblastic and even lipomatous differentiation may manifest as a densely collagenous mass. It is the purpose of this review to highlight these collagen-rich soft tissue tumors.

Original languageEnglish (US)
Pages (from-to)179-199
Number of pages21
JournalAdvances in anatomic pathology
Issue number4
StatePublished - Jul 2003
Externally publishedYes


  • Collagen
  • Fibroblast
  • Fibrous
  • Myofibroblast
  • Soft tissue tumor
  • Spindle cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy


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