Collagen corneal shields enhance penetration of topical prednisolone acetate

Mark R. Sawusch, Terrence P. O'Brien, Stephen A. Updegraff

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We used an animal model to compare the corneal and aqueous penetration of topical prednisolone acetate 1% with and without the presence of a commercially available collagen corneal shield. A significant P < .02) increase in penetration into cornea and aqueous humor at 30 minutes and 120 minutes was found in eyes with a collagen corneal shield in place. Increased concentrations were achieved by soaking the shield in prednisolone acetate for 15 minutes prior to application.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
JournalJournal of cataract and refractive surgery
Volume15
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Keywords

  • aqueous
  • collagen corneal shield
  • cornea
  • drug delivery
  • prednisolone acetate

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems

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