Abstract
There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 309-315 |
| Number of pages | 7 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 21 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - May 1 2006 |
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Keywords
- Alzheimer's disease
- Mild cognitive impairment
- Mild cognitive impairment vascular subtypes
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Geriatrics and Gerontology
Cite this
Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies. / Loewenstein, David; Acevedo, Amarilis; Agron, Joscelyn; Issacson, Richard; Strauman, Silvia; Crocco, Elizabeth; Barker, Warren W.; Duara, Ranjan.
In: Dementia and Geriatric Cognitive Disorders, Vol. 21, No. 5-6, 01.05.2006, p. 309-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies
AU - Loewenstein, David
AU - Acevedo, Amarilis
AU - Agron, Joscelyn
AU - Issacson, Richard
AU - Strauman, Silvia
AU - Crocco, Elizabeth
AU - Barker, Warren W.
AU - Duara, Ranjan
PY - 2006/5/1
Y1 - 2006/5/1
N2 - There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.
AB - There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.
KW - Alzheimer's disease
KW - Mild cognitive impairment
KW - Mild cognitive impairment vascular subtypes
UR - http://www.scopus.com/inward/record.url?scp=33646683828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646683828&partnerID=8YFLogxK
U2 - 10.1159/000091522
DO - 10.1159/000091522
M3 - Article
C2 - 16490966
AN - SCOPUS:33646683828
VL - 21
SP - 309
EP - 315
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 5-6
ER -