Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies

David A. Loewenstein, Amarilis Acevedo, Joscelyn Agron, Richard Issacson, Silvia Strauman, Elizabeth Crocco, Warren W. Barker, Ranjan Duara

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume21
Issue number5-6
DOIs
StatePublished - May 1 2006

Keywords

  • Alzheimer's disease
  • Mild cognitive impairment
  • Mild cognitive impairment vascular subtypes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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