Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies

David Loewenstein, Amarilis Acevedo, Joscelyn Agron, Richard Issacson, Silvia Strauman, Elizabeth Crocco, Warren W. Barker, Ranjan Duara

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume21
Issue number5-6
DOIs
StatePublished - May 1 2006

Fingerprint

Alzheimer Disease
Blood Vessels
Cognitive Dysfunction
Executive Function
Vascular Diseases
Dementia
Language
Research

Keywords

  • Alzheimer's disease
  • Mild cognitive impairment
  • Mild cognitive impairment vascular subtypes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies. / Loewenstein, David; Acevedo, Amarilis; Agron, Joscelyn; Issacson, Richard; Strauman, Silvia; Crocco, Elizabeth; Barker, Warren W.; Duara, Ranjan.

In: Dementia and Geriatric Cognitive Disorders, Vol. 21, No. 5-6, 01.05.2006, p. 309-315.

Research output: Contribution to journalArticle

Loewenstein, David ; Acevedo, Amarilis ; Agron, Joscelyn ; Issacson, Richard ; Strauman, Silvia ; Crocco, Elizabeth ; Barker, Warren W. ; Duara, Ranjan. / Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies. In: Dementia and Geriatric Cognitive Disorders. 2006 ; Vol. 21, No. 5-6. pp. 309-315.
@article{d9200ad1079a46f5aede33152e6ea22b,
title = "Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies",
abstract = "There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.",
keywords = "Alzheimer's disease, Mild cognitive impairment, Mild cognitive impairment vascular subtypes",
author = "David Loewenstein and Amarilis Acevedo and Joscelyn Agron and Richard Issacson and Silvia Strauman and Elizabeth Crocco and Barker, {Warren W.} and Ranjan Duara",
year = "2006",
month = "5",
day = "1",
doi = "10.1159/000091522",
language = "English",
volume = "21",
pages = "309--315",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "5-6",

}

TY - JOUR

T1 - Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies

AU - Loewenstein, David

AU - Acevedo, Amarilis

AU - Agron, Joscelyn

AU - Issacson, Richard

AU - Strauman, Silvia

AU - Crocco, Elizabeth

AU - Barker, Warren W.

AU - Duara, Ranjan

PY - 2006/5/1

Y1 - 2006/5/1

N2 - There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.

AB - There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/ praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.

KW - Alzheimer's disease

KW - Mild cognitive impairment

KW - Mild cognitive impairment vascular subtypes

UR - http://www.scopus.com/inward/record.url?scp=33646683828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646683828&partnerID=8YFLogxK

U2 - 10.1159/000091522

DO - 10.1159/000091522

M3 - Article

C2 - 16490966

AN - SCOPUS:33646683828

VL - 21

SP - 309

EP - 315

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 5-6

ER -