Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder

Robert L. Trestman, Richard S.E. Keefe, Vivian Mitropoulou, Philip D. Harvey, Marie L. deVegvar, Sonia Lees-Roitman, Michael Davidson, Andrew Aronson, Jeremy Silverman, Larry J. Siever

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

There is evidence that some schizophrenic patients have deficits on tests of cognitive function, particularly tests of executive function, including the Wisconsin Card Sorting Test (WCST) and the Trail-making Test, Part B. This study was conducted to determine the generalizability of these findings across the schizophrenia spectrum to schizotypal personality disorder (SPD). Forty DSM-III SPD patients, 56 nonschizophrenia-related other personality disorder (OPD) patients, and 32 normal volunteers from two medical centers performed tests of executive function such as the WCST, Trail-making Part B, Stroop Word-Color Test, and Verbal Fluency, as well as tests of more general intellectual functioning such as the Wechsler Intelligence Scale-Revised Vocabulary and Block Design subtests, and Trail-making Part A. SPD patients performed more poorly on the WCST and on Trail-making Part B than did OPD patients or normal subjects; the groups did not differ on tests of general intellectual functioning. SPD patients may share some of the cognitive deficits observed in schizophrenia.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalPsychiatry Research
Volume59
Issue number1-2
DOIs
StatePublished - Nov 29 1995
Externally publishedYes

Keywords

  • Neuropsychology
  • Personality disorder
  • Schizophrenia spectrum
  • Trail-making Test Part B
  • Wisconsin Card Sorting Test

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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    Trestman, R. L., Keefe, R. S. E., Mitropoulou, V., Harvey, P. D., deVegvar, M. L., Lees-Roitman, S., Davidson, M., Aronson, A., Silverman, J., & Siever, L. J. (1995). Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder. Psychiatry Research, 59(1-2), 127-136. https://doi.org/10.1016/0165-1781(95)02709-2