Abstract
Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe across several domains, including attention, working memory, verbal learning and memory, and executive functions. These deficits pre-date the onset of frank psychosis and are stable throughout the course of the illness in most patients. Over the past decade, the focus on these deficits has increased dramatically with the recognition that they are consistently the best predictor of functional outcomes across outcome domains and patient samples. Recent treatment studies, both pharmacological and behavioral, suggest that cognitive deficits are malleable. Other research calls into question the meaningfulness of cognitive change in schizophrenia. In this article, we review cognitive deficits in schizophrenia and focus on their treatment and relationship to functional outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 531-536 |
| Number of pages | 6 |
| Journal | Neuropsychiatric Disease and Treatment |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2006 |
| Externally published | Yes |
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Keywords
- Cognition
- Functional skills
- Outcome
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Cognitive deficits and functional outcome in schizophrenia. / Bowie, Christopher R.; Harvey, Philip D.
In: Neuropsychiatric Disease and Treatment, Vol. 2, No. 4, 01.12.2006, p. 531-536.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive deficits and functional outcome in schizophrenia
AU - Bowie, Christopher R.
AU - Harvey, Philip D
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe across several domains, including attention, working memory, verbal learning and memory, and executive functions. These deficits pre-date the onset of frank psychosis and are stable throughout the course of the illness in most patients. Over the past decade, the focus on these deficits has increased dramatically with the recognition that they are consistently the best predictor of functional outcomes across outcome domains and patient samples. Recent treatment studies, both pharmacological and behavioral, suggest that cognitive deficits are malleable. Other research calls into question the meaningfulness of cognitive change in schizophrenia. In this article, we review cognitive deficits in schizophrenia and focus on their treatment and relationship to functional outcome.
AB - Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe across several domains, including attention, working memory, verbal learning and memory, and executive functions. These deficits pre-date the onset of frank psychosis and are stable throughout the course of the illness in most patients. Over the past decade, the focus on these deficits has increased dramatically with the recognition that they are consistently the best predictor of functional outcomes across outcome domains and patient samples. Recent treatment studies, both pharmacological and behavioral, suggest that cognitive deficits are malleable. Other research calls into question the meaningfulness of cognitive change in schizophrenia. In this article, we review cognitive deficits in schizophrenia and focus on their treatment and relationship to functional outcome.
KW - Cognition
KW - Functional skills
KW - Outcome
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=33847315633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847315633&partnerID=8YFLogxK
U2 - 10.2147/nedt.2006.2.4.531
DO - 10.2147/nedt.2006.2.4.531
M3 - Article
C2 - 19412501
AN - SCOPUS:33847315633
VL - 2
SP - 531
EP - 536
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
SN - 1176-6328
IS - 4
ER -