Cognitive Deficits after Cerebral Ischemia and Underlying Dysfunctional Plasticity: Potential Targets for Recovery of Cognition

Holly M. Stradecki-Cohan, Charles H. Cohan, Ami Raval, Kunjan R Dave, Diego Reginensi, Rolando A. Gittens, Mehdi Youbi, Miguel Perez-Pinzon

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Cerebral ischemia affects millions of people worldwide and survivors suffer from long-term functional and cognitive deficits. While stroke and cardiac arrest are typically considered when discussing ischemic brain injuries, there is much evidence that smaller ischemic insults underlie neurodegenerative diseases, including Alzheimer's disease. The "regenerative" capacity of the brain relies on several aspects of plasticity that are crucial for normal functioning; less affected brain areas may take over function previously performed by irreversibly damaged tissue. To harness the endogenous plasticity mechanisms of the brain to provide recovery of cognitive function, we must first understand how these mechanisms are altered after damage, such as cerebral ischemia. In this review, we discuss the long-term cognitive changes that result after cerebral ischemia and how ischemia alters several plasticity processes. We conclude with a discussion of how current and prospective therapies may restore brain plasticity and allow for recovery of cognitive function, which may be applicable to several disorders that have a disruption of cognitive processing, including traumatic brain injury and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)S87-S105
JournalJournal of Alzheimer's Disease
Volume60
Issue numbers1
DOIs
StatePublished - 2017

Keywords

  • Biocompatible materials
  • brain ischemia
  • cognition
  • heart arrest
  • neuronal plasticity
  • stem cells
  • stroke
  • synapse

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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