Cognitive correlates of white matter lesion load and brain atrophy

Chuanhui Dong, Nooshin Nabizadeh, Michelle Caunca, Ying Kuen Cheung, Tatjana Rundek, Mitchell S V Elkind, Charles Decarli, Ralph L Sacco, Yaakov Stern, Clinton B Wright

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: We investigated white matter lesion load and global and regional brain volumes in relation to domain-specific cognitive performance in the stroke-free Northern Manhattan Study (NOMAS) population. Methods: We quantified white matter hyperintensity volume (WMHV), total cerebral volume (TCV), and total lateral ventricular (TLV) volume, as well as hippocampal and cortical gray matter (GM) lobar volumes in a subgroup. We used general linear models to examine MRI markers in relation to domain-specific cognitive performance, adjusting for key covariates. Results: MRI and cognitive data were available for 1,163 participants (mean age 70 ± 9 years; 60% women; 66% Hispanic, 17% black, 15% white). Across the entire sample, those with greater WMHV had worse processing speed. Those with larger TLV volume did worse on episodic memory, processing speed, and semantic memory tasks, and TCV did not explain domain-specific variability in cognitive performance independent of other measures. Age was an effect modifier, and stratified analysis showed that TCV and WMHV explained variability in some domains above age 70. Smaller hippocampal volume was associated with worse performance across domains, even after adjusting for APOE ε4 and vascular risk factors, whereas smaller frontal lobe volumes were only associated with worse executive function. Conclusions: In this racially/ethnically diverse, community-based sample, white matter lesion load was inversely associated with cognitive performance, independent of brain atrophy. Lateral ventricular, hippocampal, and lobar GM volumes explained domain-specific variability in cognitive performance.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalNeurology
Volume85
Issue number5
DOIs
StatePublished - Aug 4 2015

Fingerprint

Atrophy
Brain
Episodic Memory
Executive Function
Frontal Lobe
Hispanic Americans
Semantics
Linear Models
Stroke
White Matter
Population
Gray Matter

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Dong, C., Nabizadeh, N., Caunca, M., Cheung, Y. K., Rundek, T., Elkind, M. S. V., ... Wright, C. B. (2015). Cognitive correlates of white matter lesion load and brain atrophy. Neurology, 85(5), 441-449. https://doi.org/10.1212/WNL.0000000000001716

Cognitive correlates of white matter lesion load and brain atrophy. / Dong, Chuanhui; Nabizadeh, Nooshin; Caunca, Michelle; Cheung, Ying Kuen; Rundek, Tatjana; Elkind, Mitchell S V; Decarli, Charles; Sacco, Ralph L; Stern, Yaakov; Wright, Clinton B.

In: Neurology, Vol. 85, No. 5, 04.08.2015, p. 441-449.

Research output: Contribution to journalArticle

Dong, C, Nabizadeh, N, Caunca, M, Cheung, YK, Rundek, T, Elkind, MSV, Decarli, C, Sacco, RL, Stern, Y & Wright, CB 2015, 'Cognitive correlates of white matter lesion load and brain atrophy', Neurology, vol. 85, no. 5, pp. 441-449. https://doi.org/10.1212/WNL.0000000000001716
Dong, Chuanhui ; Nabizadeh, Nooshin ; Caunca, Michelle ; Cheung, Ying Kuen ; Rundek, Tatjana ; Elkind, Mitchell S V ; Decarli, Charles ; Sacco, Ralph L ; Stern, Yaakov ; Wright, Clinton B. / Cognitive correlates of white matter lesion load and brain atrophy. In: Neurology. 2015 ; Vol. 85, No. 5. pp. 441-449.
@article{c4378153fee6492caa3a61399f39d582,
title = "Cognitive correlates of white matter lesion load and brain atrophy",
abstract = "Objective: We investigated white matter lesion load and global and regional brain volumes in relation to domain-specific cognitive performance in the stroke-free Northern Manhattan Study (NOMAS) population. Methods: We quantified white matter hyperintensity volume (WMHV), total cerebral volume (TCV), and total lateral ventricular (TLV) volume, as well as hippocampal and cortical gray matter (GM) lobar volumes in a subgroup. We used general linear models to examine MRI markers in relation to domain-specific cognitive performance, adjusting for key covariates. Results: MRI and cognitive data were available for 1,163 participants (mean age 70 ± 9 years; 60{\%} women; 66{\%} Hispanic, 17{\%} black, 15{\%} white). Across the entire sample, those with greater WMHV had worse processing speed. Those with larger TLV volume did worse on episodic memory, processing speed, and semantic memory tasks, and TCV did not explain domain-specific variability in cognitive performance independent of other measures. Age was an effect modifier, and stratified analysis showed that TCV and WMHV explained variability in some domains above age 70. Smaller hippocampal volume was associated with worse performance across domains, even after adjusting for APOE ε4 and vascular risk factors, whereas smaller frontal lobe volumes were only associated with worse executive function. Conclusions: In this racially/ethnically diverse, community-based sample, white matter lesion load was inversely associated with cognitive performance, independent of brain atrophy. Lateral ventricular, hippocampal, and lobar GM volumes explained domain-specific variability in cognitive performance.",
author = "Chuanhui Dong and Nooshin Nabizadeh and Michelle Caunca and Cheung, {Ying Kuen} and Tatjana Rundek and Elkind, {Mitchell S V} and Charles Decarli and Sacco, {Ralph L} and Yaakov Stern and Wright, {Clinton B}",
year = "2015",
month = "8",
day = "4",
doi = "10.1212/WNL.0000000000001716",
language = "English (US)",
volume = "85",
pages = "441--449",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Cognitive correlates of white matter lesion load and brain atrophy

AU - Dong, Chuanhui

AU - Nabizadeh, Nooshin

AU - Caunca, Michelle

AU - Cheung, Ying Kuen

AU - Rundek, Tatjana

AU - Elkind, Mitchell S V

AU - Decarli, Charles

AU - Sacco, Ralph L

AU - Stern, Yaakov

AU - Wright, Clinton B

PY - 2015/8/4

Y1 - 2015/8/4

N2 - Objective: We investigated white matter lesion load and global and regional brain volumes in relation to domain-specific cognitive performance in the stroke-free Northern Manhattan Study (NOMAS) population. Methods: We quantified white matter hyperintensity volume (WMHV), total cerebral volume (TCV), and total lateral ventricular (TLV) volume, as well as hippocampal and cortical gray matter (GM) lobar volumes in a subgroup. We used general linear models to examine MRI markers in relation to domain-specific cognitive performance, adjusting for key covariates. Results: MRI and cognitive data were available for 1,163 participants (mean age 70 ± 9 years; 60% women; 66% Hispanic, 17% black, 15% white). Across the entire sample, those with greater WMHV had worse processing speed. Those with larger TLV volume did worse on episodic memory, processing speed, and semantic memory tasks, and TCV did not explain domain-specific variability in cognitive performance independent of other measures. Age was an effect modifier, and stratified analysis showed that TCV and WMHV explained variability in some domains above age 70. Smaller hippocampal volume was associated with worse performance across domains, even after adjusting for APOE ε4 and vascular risk factors, whereas smaller frontal lobe volumes were only associated with worse executive function. Conclusions: In this racially/ethnically diverse, community-based sample, white matter lesion load was inversely associated with cognitive performance, independent of brain atrophy. Lateral ventricular, hippocampal, and lobar GM volumes explained domain-specific variability in cognitive performance.

AB - Objective: We investigated white matter lesion load and global and regional brain volumes in relation to domain-specific cognitive performance in the stroke-free Northern Manhattan Study (NOMAS) population. Methods: We quantified white matter hyperintensity volume (WMHV), total cerebral volume (TCV), and total lateral ventricular (TLV) volume, as well as hippocampal and cortical gray matter (GM) lobar volumes in a subgroup. We used general linear models to examine MRI markers in relation to domain-specific cognitive performance, adjusting for key covariates. Results: MRI and cognitive data were available for 1,163 participants (mean age 70 ± 9 years; 60% women; 66% Hispanic, 17% black, 15% white). Across the entire sample, those with greater WMHV had worse processing speed. Those with larger TLV volume did worse on episodic memory, processing speed, and semantic memory tasks, and TCV did not explain domain-specific variability in cognitive performance independent of other measures. Age was an effect modifier, and stratified analysis showed that TCV and WMHV explained variability in some domains above age 70. Smaller hippocampal volume was associated with worse performance across domains, even after adjusting for APOE ε4 and vascular risk factors, whereas smaller frontal lobe volumes were only associated with worse executive function. Conclusions: In this racially/ethnically diverse, community-based sample, white matter lesion load was inversely associated with cognitive performance, independent of brain atrophy. Lateral ventricular, hippocampal, and lobar GM volumes explained domain-specific variability in cognitive performance.

UR - http://www.scopus.com/inward/record.url?scp=84938565517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938565517&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000001716

DO - 10.1212/WNL.0000000000001716

M3 - Article

C2 - 26156514

AN - SCOPUS:84938565517

VL - 85

SP - 441

EP - 449

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -