Cognitive changes in asymptomatic drug-naïve human immunodeficiency virus type 1 clade C infection

K. Gopukumar, Shobini Rao, P. Satishchandra, Jayashree Dasgupta, Ronald Ellis, D. K. Subbakrishna, P. Mariamma, Anupa Kamat, Anita Desai, V. Ravi, B. S. Rao, K. S. Satish, Mahendra Kumar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Asymptomatic human immunodeficiency virus (HIV) infection is associated with impaired cognitive functioning in both clade B and C infections. The nature of cognitive change longitudinally has not been studied in asymptomatic clade C infection. The present study evaluated changes in neuropsychological functioning over a 2 1/2-year period in a cohort of HIV-1 clade C-infected asymptomatic individuals from South India. Participants with CD4 counts below 250 were started on highly active antiretroviral therapy (HAART) as per National AIDS Control Organisation NACO guidelines and hence excluded. The sample consisted of 68 patients (30 men and 38 women), with a mean age of 29.4 years (SD=5.6 years) and a mean education of 10.0 years (SD=2.7 years). A comprehensive neuropsychological assessment with 12 tests yielding 21 variables was used to examine cognitive functioning at baseline and subsequently at 6-monthly intervals for five follow-ups. Shift in CD4 and viral load categories measured by the McNemar's test indicated disease progression. Latent growth curve (LGC) modeling assessed the nature of change in cognition over the 2 1/2-year study period. Ten variables representing attention, executive functions, and long-term memory fit the LGC model. Excepting visual working memory, the slope was nonsignificant for nine variables, indicating absence of deterioration in cognition over a 2 1/ 2-year period. However, CD4 and viral load levels worsened, indicating disease progression. Asymptomatic individuals with HIV-1 clade C infection do not show any significant decline on individual neuropsychological functions over 2 1/2 years despite disease progression, as evidenced by immune suppression and viral loads.

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalJournal of NeuroVirology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2008

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Viral Load
Disease Progression
HIV-1
Cognition
Infection
Pharmaceutical Preparations
Long-Term Memory
Executive Function
Highly Active Antiretroviral Therapy
Virus Diseases
CD4 Lymphocyte Count
Growth
Short-Term Memory
India
Acquired Immunodeficiency Syndrome
HIV
Guidelines
Education

Keywords

  • Cognition
  • HIV I clade C
  • Natural history

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Cognitive changes in asymptomatic drug-naïve human immunodeficiency virus type 1 clade C infection. / Gopukumar, K.; Rao, Shobini; Satishchandra, P.; Dasgupta, Jayashree; Ellis, Ronald; Subbakrishna, D. K.; Mariamma, P.; Kamat, Anupa; Desai, Anita; Ravi, V.; Rao, B. S.; Satish, K. S.; Kumar, Mahendra.

In: Journal of NeuroVirology, Vol. 14, No. 6, 01.12.2008, p. 480-485.

Research output: Contribution to journalArticle

Gopukumar, K, Rao, S, Satishchandra, P, Dasgupta, J, Ellis, R, Subbakrishna, DK, Mariamma, P, Kamat, A, Desai, A, Ravi, V, Rao, BS, Satish, KS & Kumar, M 2008, 'Cognitive changes in asymptomatic drug-naïve human immunodeficiency virus type 1 clade C infection', Journal of NeuroVirology, vol. 14, no. 6, pp. 480-485. https://doi.org/10.1080/13550280802304746
Gopukumar K, Rao S, Satishchandra P, Dasgupta J, Ellis R, Subbakrishna DK et al. Cognitive changes in asymptomatic drug-naïve human immunodeficiency virus type 1 clade C infection. Journal of NeuroVirology. 2008 Dec 1;14(6):480-485. https://doi.org/10.1080/13550280802304746
Gopukumar, K. ; Rao, Shobini ; Satishchandra, P. ; Dasgupta, Jayashree ; Ellis, Ronald ; Subbakrishna, D. K. ; Mariamma, P. ; Kamat, Anupa ; Desai, Anita ; Ravi, V. ; Rao, B. S. ; Satish, K. S. ; Kumar, Mahendra. / Cognitive changes in asymptomatic drug-naïve human immunodeficiency virus type 1 clade C infection. In: Journal of NeuroVirology. 2008 ; Vol. 14, No. 6. pp. 480-485.
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