Cognitive-behavioral stress management intervention effects on anxiety, 24-hr urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay men

Michael H. Antoni, Dean G. Cruess, Stacy Cruess, Susan Lutgendorf, Mahendra Kumar, Gail Ironson, Nancy Klimas, Mary Ann Fletcher, Neil Schneiderman

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The present study tested the effects of a multimodal cognitive- behavioral stress management (CBSM) intervention on anxious mood, perceived stress, 24-hr urinary catecholamine levels, and changes in T-lymphocyte subpopulations over time in symptomatic HIV+ gay men. Seventy-three men were randomized to either a group-based CBSM intervention (n = 47) or a wait-list control (WLC) condition (n = 26). Men assigned to CBSM showed significantly lower posttreatment levels of self-reported anxiety, anger, total mood disturbance, and perceived stress and less norepinephrine (NE) output as compared with men in the WLC group. At the individual level, anxiety decreases paralleled NE reductions. Significantly greater numbers of T- cytotoxic/suppressor (CD3+CD8+) lymphocytes were found 6 to 12 months later in those assigned to CBSM. Moreover, greater decreases in NE output and a greater frequency of relaxation home practice during the 10-week CBSM intervention period predicted higher CD3+CD8+ cell counts at follow-up.

Original languageEnglish (US)
Pages (from-to)31-45
Number of pages15
JournalJournal of consulting and clinical psychology
Issue number1
StatePublished - Jan 1 2000


ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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