Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer

Bonnie A. McGregor, Michael H Antoni, Amy Boyers, Susan M. Alferi, Bonnie B Blomberg, Charles S Carver

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Objective: This study examined the effect of a cognitive-behavioral stress management (CBSM) intervention on emotional well-being and immune function among women in the months following surgery for early-stage breast cancer. Method: Twenty-nine women were randomly assigned to receive either a 10-week CBSM intervention (n=18) or a comparison experience (n=11). The primary psychological outcome measure was benefit finding. The primary immune function outcome measure was in vitro lymphocyte proliferative response to anti CD3. Results: Women in the CBSM intervention reported greater perceptions of benefit from having breast cancer compared to the women in the comparison group. At 3-month follow-up, women in the CBSM group also had improved lymphocyte proliferation. Finally, increases in benefit finding after the 10-week intervention predicted increases in lymphocyte proliferation at the 3-month follow-up. Conclusion: A CBSM intervention for women with early-stage breast cancer facilitated positive emotional responses to their breast cancer experience in parallel with later improvement in cellular immune function.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Psychosomatic Research
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2004

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Breast Neoplasms
Lymphocytes
Outcome Assessment (Health Care)
Psychology

Keywords

  • Anti-CD3
  • Breast neoplasms
  • Cognitive-behavioral therapy
  • Intervention studies
  • Lymphocyte proliferation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer. / McGregor, Bonnie A.; Antoni, Michael H; Boyers, Amy; Alferi, Susan M.; Blomberg, Bonnie B; Carver, Charles S.

In: Journal of Psychosomatic Research, Vol. 56, No. 1, 01.01.2004, p. 1-8.

Research output: Contribution to journalArticle

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