Cognitive and functional effects of atypical antipsychotic medications.

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13 Scopus citations


Several meta-analyses and some direct comparative studies of atypical antipsychotics indicate that these medications may be more effective than conventional antipsychotic medications at enhancing cognition. However, differences in studies exist: short-term studies of cognitive enhancement may not provide similar results to long-term studies, while comparative studies are superior to meta-analyses. Direct measurement of changes in functional capacity may be a desirable study feature, and the population studied, including the treatment subjects receive, is likely to have a substantial impact on the results. Additionally, cognitive enhancement is not a stand-alone phenomenon. Depression and negative symptoms, for example, also affect an individual with schizophrenia and his or her functioning in the real world as opposed to within clinical studies.

Original languageEnglish (US)
Pages (from-to)e13
JournalThe Journal of clinical psychiatry
Issue number10
StatePublished - Oct 2006
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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