TY - JOUR
T1 - Cognitive and functional effects of atypical antipsychotic medications.
AU - Harvey, Philip D.
PY - 2006/10
Y1 - 2006/10
N2 - Several meta-analyses and some direct comparative studies of atypical antipsychotics indicate that these medications may be more effective than conventional antipsychotic medications at enhancing cognition. However, differences in studies exist: short-term studies of cognitive enhancement may not provide similar results to long-term studies, while comparative studies are superior to meta-analyses. Direct measurement of changes in functional capacity may be a desirable study feature, and the population studied, including the treatment subjects receive, is likely to have a substantial impact on the results. Additionally, cognitive enhancement is not a stand-alone phenomenon. Depression and negative symptoms, for example, also affect an individual with schizophrenia and his or her functioning in the real world as opposed to within clinical studies.
AB - Several meta-analyses and some direct comparative studies of atypical antipsychotics indicate that these medications may be more effective than conventional antipsychotic medications at enhancing cognition. However, differences in studies exist: short-term studies of cognitive enhancement may not provide similar results to long-term studies, while comparative studies are superior to meta-analyses. Direct measurement of changes in functional capacity may be a desirable study feature, and the population studied, including the treatment subjects receive, is likely to have a substantial impact on the results. Additionally, cognitive enhancement is not a stand-alone phenomenon. Depression and negative symptoms, for example, also affect an individual with schizophrenia and his or her functioning in the real world as opposed to within clinical studies.
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U2 - 10.4088/jcp.1006e13
DO - 10.4088/jcp.1006e13
M3 - Article
C2 - 17107236
AN - SCOPUS:34249936725
VL - 67
SP - e13
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - 10
ER -